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首页> 外文期刊>Pain Research and Treatment >The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain: A Randomized Double-Blinded Placebo-Controlled Trial
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The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain: A Randomized Double-Blinded Placebo-Controlled Trial

机译：静脉地塞米松和利多卡因对异丙酚诱发的血管痛的影响：随机双盲安慰剂对照试验。

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Background.The mechanism for pain associated with intravenous administration of propofol is believed to be related to the release of nitric oxide. We hypothesized that pain following propofol injection would be reduced by pretreatment with dexamethasone.Methods.One hundred fourteen female subjects received 5 mL of preservative-free saline, 0.5 mg·kg−1of lignocaine hydrochloride 10 mg·mL−1or 0.25 mg·kg−1of dexamethasone, intravenously, following exsanguination and occlusion of the veins of the arm. This was followed by a 0.5 mg·kg−1injection of propofol. Pain scores, facial grimacing, arm withdrawal, and vocalization were recorded prior to and at 15 and 30 seconds following the injection of propofol.Results.The incidence of moderate to severe pain following the injection of propofol was significantly decreased with both lidocaine and dexamethasone. Hand withdrawal was also significantly decreased in comparison to saline.Conclusion.Low dose dexamethasone is commonly used as an antiemetic, and, in larger doses, it has been demonstrated to provide prolonged postoperative analgesia. At higher analgesic doses, dexamethasone may also reduce pain associated with the injection of propofol. This effect is probably related to the effect of the steroid on nitric oxide production associated with intravenous propofol injection.
机译：背景技术与异丙酚静脉给药有关的疼痛机制被认为与一氧化氮的释放有关。我们假设通过地塞米松预处理可以减轻丙泊酚注射后的疼痛。方法：114名女性受试者接受5μmL不含防腐剂的生理盐水，0.5μmg·kg-1盐酸利多卡因10μmg·mL-1或0.25μmg·kg-放血并阻塞手臂静脉后，静脉注射地塞米松1片。随后注射0.5μmg·kg-1的异丙酚。在注射丙泊酚之前和之后15和30秒记录疼痛评分，面部做鬼脸，手臂缩回和发声。结果。利多卡因和地塞米松同时注射丙泊酚后中度至重度疼痛的发生率显着降低。与盐水相比，手的撤离也显着减少。结论。低剂量地塞米松通常用作止吐药，大剂量地塞米松已被证明可以延长术后镇痛时间。在较高的镇痛剂量下，地塞米松还可减轻与异丙酚注射有关的疼痛。该作用可能与类固醇对与静脉注射异丙酚注射有关的一氧化氮产生的作用有关。

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