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首页> 外文期刊>Pain Research and Treatment >Perineural Dexamethasone to Improve Postoperative Analgesia with Peripheral Nerve Blocks: A Meta-Analysis of Randomized Controlled Trials
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Perineural Dexamethasone to Improve Postoperative Analgesia with Peripheral Nerve Blocks: A Meta-Analysis of Randomized Controlled Trials

机译：神经周围地塞米松改善周围神经阻滞术后镇痛：随机对照试验的荟萃分析。

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Background. The overall effect of perineural dexamethasone on postoperative analgesia outcomes has yet to be quantified. The main objective of this quantitative review was to evaluate the effect of perineural dexamethasone as a nerve block adjunct on postoperative analgesia outcomes.Methods. A systematic search was performed to identify randomized controlled trials that evaluated the effects of perineural dexamethasone as a block adjunct on postoperative pain outcomes in patients receiving regional anesthesia. Meta-analysis was performed using a random-effect model.Results. Nine randomized trials with 760 subjects were included. The weighted mean difference (99% CI) of the combined effects favored perineural dexamethasone over control for analgesia duration, 473 (264 to 682) minutes, and motor block duration, 500 (154 to 846) minutes. Postoperative opioid consumption was also reduced in the perineural dexamethasone group compared to control, −8.5 (−12.3 to −4.6) mg of IV morphine equivalents. No significant neurological symptoms could have been attributed to the use of perineural dexamethasone.Conclusions. Perineural dexamethasone improves postoperative pain outcomes when given as an adjunct to brachial plexus blocks. There were no reports of persistent nerve injury attributed to perineural administration of the drug.
机译：背景。神经周围地塞米松对术后镇痛效果的总体影响尚未量化。这项定量研究的主要目的是评估神经神经辅助药神经周地塞米松对术后镇痛效果的影响。进行了系统的搜索，以鉴定随机对照试验，该试验评估了神经痛性地塞米松作为阻滞剂对接受局部麻醉的患者术后疼痛结局的影响。使用随机效应模型进行荟萃分析。包括9个760名受试者的随机试验。联合作用的加权平均差异（99％CI）有利于神经痛性地塞米松优于对照，镇痛持续时间为473（264至682）分钟，运动阻滞持续时间为500（154至846）分钟。与对照组相比，静脉内吗啡当量-8.5 mg（-12.3至-4.6）mg的神经周围地塞米松组术后阿片类药物的消耗也减少了。没有明显的神经系统症状可归因于神经周围地塞米松的使用。当与臂丛神经阻滞配合使用时，神经周围地塞米松可改善术后疼痛结局。没有关于归因于神经鞘内给药的持续性神经损伤的报道。

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