Melatonin in Pain Modulation: Analgesic or Proalgesic?

Yongliang Liu; Hongwen He; Fang Huang

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Melatonin in Pain Modulation: Analgesic or Proalgesic?

机译：疼痛调节中的褪黑素：止痛还是镇痛？

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Melatonin, as an endogenous hormone produced mainly in the pineal gland in a clear circadian fashion, has diverse physiological functions, such as the control of circadian rhythms, sleep regulation, antioxidant, etc. Recently, accumulating researches about melatonin and pain have been reported. In this review, comparison and summary about analgesic/proalgesic effect of melatonin in inflammatory and neuropathic pain will be made. Some possible pathways of melatonin involved in dual pain modulation might help to explain all these conflicting results in various situations.

机译：褪黑素是一种主要以明显的昼夜节律方式在松果体中产生的内源激素，具有多种生理功能，例如控制昼夜节律，睡眠调节，抗氧化剂等。近来，关于褪黑激素和疼痛的研究不断报道。在这篇综述中，将对褪黑激素在炎性和神经性疼痛中的镇痛/镇痛作用进行比较和总结。褪黑素参与双重疼痛调节的一些可能途径可能有助于解释在各种情况下所有这些矛盾的结果。

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《Pain Studies and Treatment》 |2014年第2期|共6页
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Yongliang Liu; Hongwen He; Fang Huang;
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机译：小鼠强直痛反应的昼夜变化：褪黑素具有镇痛作用的证据。
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机译：褪黑素在人炎症疼痛模型中的镇痛和抗震术效应：随机，双盲，安慰剂控制，三臂交叉研究
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机译：新生儿重症监护中的疼痛：褪黑激素作为止痛抗氧化剂的作用
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机译：加布普坦单独的镇痛作用，或与犬犬在狗中与神经病疼痛组合的影响
5. Use of Non-Opioid Analgesics as First Line Treatment for Acute Pain Management by Emergency Medical Services Providers [D] . Shiba, Steven Kiyohiko. 2019

机译：使用非阿片类镇痛药作为紧急医疗服务提供商急性疼痛管理的第一线治疗
6. Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective observational Optimizing Patient Experience and Response to Topical Analgesics study [O] . Jeffrey A Gudin, Michael J Brennan, E Dennis Harris, 2017

机译：复合式局部镇痛药治疗慢性疼痛后疼痛的变化和同时使用止痛药的变化：前瞻性观察性优化患者体验和对局部镇痛药研究的反应的3个月和6个月随访结果
7. Melatonin in Pain Modulation: Analgesic or Proalgesic? [O] . Yongliang Liu, Hongwen He, Fang Huang 2014

机译：褪黑素在疼痛调节中：镇痛或预级别？

Melatonin in Pain Modulation: Analgesic or Proalgesic?

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