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Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

机译：子宫内膜癌组织中COX-2，GLUT-1和VEGF表达的临床意义

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Objective: To analyze the clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues.Methods: One hundred and eight tissue samples from the patients with endometrial cancer enrolled in our hospital from August 2011 to July 2014 were selected, including 60 normal tissue samples (normal group), 60 neoplastic tissue samples (neoplastic group) and 60 cancer tissue samples (cancer group). All the samples were subjected to immunohistochemical assay to detect the expressions of COX-2, GLUT-1 and VEGF. The clinical data were also investigated for correlation analysis.Results: The positive rates of COX-2 in normal group, neoplastic group and cancer groups were 3.3%, 21.7% and 55.0% respectively. The positive rates of GLUT-1 in normal group, neoplastic group and cancer groups were 3.3%, 25.0% and 70.0% respectively. The positive rates of VEGF in normal group, neoplastic group and cancer groups were 1.7%, 23.3% and 63.3% respectively. With increasing stage of such cancer, decreasing degree of differentiation and lymphatic metastasis, the positive expression rates of COX-2, GLUT-1 and VEGF proteins were raised significantly (P<0.05). Spearman’s correlation analysis showed that the expressions of COX-2 and GLUT-1 (r=0.207, P<0.05), COX-2 and VEGF (r=0.243, P<0.05), as well as GLUT-1 and VEGF (r=0.758, P<0.05) were positively correlated.Conclusion: COX-2, GLUT-1 and VEGF were highly prominent in endometrial cancer, especially in the patients with low degree of differentiation, late stage and metastasis. They functioned synergistically in the onset and progression of this cancer.doi: http://dx.doi.org/10.12669/pjms.312.6604How to cite this:Ma X, Hui Y, Lin L, Wu Y, Zhang X, Liu P. Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. Pak J Med Sci 2015;31(2):280-284. doi: http://dx.doi.org/10.12669/pjms.312.6604This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
机译：目的：分析子宫内膜癌组织中COX-2，GLUT-1和VEGF的表达的临床意义。方法：选择2011年8月至2014年7月在我院就诊的子宫内膜癌患者108份。包括60例正常组织样本（正常组），60例肿瘤组织样本（肿瘤组）和60例癌组织样本（癌症组）。对所有样品进行免疫组织化学检测，以检测COX-2，GLUT-1和VEGF的表达。结果：正常组，肿瘤组和癌症组COX-2阳性率分别为3.3％，21.7％和55.0％。正常组，肿瘤组和癌症组GLUT-1的阳性率分别为3.3％，25.0％和70.0％。正常组，肿瘤组和癌组中VEGF的阳性率分别为1.7％，23.3％和63.3％。随着该癌分期的增加，分化程度的降低和淋巴结转移的增加，COX-2，GLUT-1和VEGF蛋白的阳性表达率显着升高（P <0.05）。 Spearman相关分析表明，COX-2和GLUT-1（r = 0.207，P <0.05），COX-2和VEGF（r = 0.243，P <0.05）以及GLUT-1和VEGF（r结论：COX-2，GLUT-1和VEGF在子宫内膜癌中尤为突出，特别是在分化程度低，晚期转移的患者中，COX-2，GLUT-1和VEGF的表达呈正相关（= 0.758，P <0.05）。他们在这种癌症的发生和发展中具有协同作用。doi：http：//dx.doi.org/10.12669/pjms.312.6604如何引用此：Ma X，Hui Y，Lin L，Wu Y，Zhang X，Liu P.子宫内膜癌组织中COX-2，GLUT-1和VEGF表达的临床意义。 Pak J Med Sci 2015; 31（2）：280-284。 doi：http：//dx.doi.org/10.12669/pjms.312.6604这是根据知识共享署名许可（http://creativecommons.org/licenses/by/3.0）的条款分发的开放获取文章，只要适当引用了原始作品，便可以在任何介质中不受限制地使用，分发和复制。

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