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首页> 外文期刊>Pakistan journal of medical sciences. >Mortality in patients presenting with organophosphorus poisoning at Liaquat University of Medical and Health Sciences
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Mortality in patients presenting with organophosphorus poisoning at Liaquat University of Medical and Health Sciences

机译：利亚夸特医疗卫生大学有机磷中毒患者的死亡率

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Objective: Organophosphorus (OP) poisoning leads to high morbidity and mortality. The objective of this study was to evaluate the mortality due to Organophosphorus poisoning.? Methodology: This descriptive and analytical study was conducted at a Medical Unit-1 and Intensive Care Unit of Liaquat University Hospital (LUH) Hyderabad/Jamshoro from October 2009 to Feb 2011. All patients with suspicion of OP poisoning were admitted. Their history and clinical features were recorded. The diagnostic criteria of the study were history from parents about ingestion of organophosphorus poison and clinical signs like excessive bradycardia, salivation, meiosis and wheezing. The exclusion criteria were absence of meiosis and patients who expired in emergency department before reaching in intensive care unit or medical wards. The data was analyzed with SPSS version 11. Results: During the period of study 100 patients were studied with the diagnosis of OP poisoning divided into grades according to severity. Their age ranged 18-58 years with mean age of 37.5?9.5 years and median age was 43 years. Males were 78 (78%) and females were 22 (22%) with M/F ratio of 7.8/2.2. 20 (20%) patients were of mild severity, 40 (40%) were of moderate severity, and 40 (40%) were of severe grade. The most common route of OP exposure was ingestion 79 (79%), followed by inhalation and dermal absorption 21 (21%). The clinical features as hyper salivation, meiosis, wheezing and depressed mental status were present in all (100%) of the patients followed by lacrimation 90 (90%), bradycardia 58 (58%), hypotension 76 (76%), chest crepitations 80 (80%), vomiting 69 (69%), abdominal cramps 40 (80%). Respiratory failure was seen in 42 (42%), sepsis in 5 (5%), seizures in 9 (9%), Pulmonary edema in 19 (19%) and ARDS in 10 (10%) patients. Forty (40%) patients were given mechanical ventilation with inotropic support. Average duration of hospital stay was 4.5 days ?SD 2.5 (range 3-22) days. Out of 100 patients 82 (82%) survived and the mortality was 18 (18%). Cause of death was mainly due to respiratory failure. Conclusion: Mortality due to Organophosphate poisoning is extremely high in our part of the world. Recognition of clinical features will make easy and early diagnosis.
机译：目的：有机磷（OP）中毒会导致较高的发病率和死亡率。这项研究的目的是评估有机磷中毒导致的死亡率。方法：该描述性和分析性研究于2009年10月至2011年2月在利阿夸特大学医院（LUH）海得拉巴/贾姆绍罗1号医疗室和重症监护室进行。所有怀疑OP中毒的患者均入院。记录他们的病史和临​​床特征。该研究的诊断标准是父母关于有机磷中毒摄入的病史和临​​床症状，如心动过缓，流涎，减数分裂和喘息。排除标准为无减数分裂和在重症监护病房或医疗病房之前在急诊室就诊的患者。使用SPSS 11版对数据进行了分析。结果：在研究期间，研究了100例OP的中毒诊断，根据严重程度将其分为几级。他们的年龄为18-58岁，平均年龄为37.5-9.5岁，中位年龄为43岁。男性为78（78％），女性为22（22％），男/女比为7.8 / 2.2。轻度严重的患者为20（20％），中度严重的患者为40（40％），重度患者为40（40％）。 OP暴露的最常见途径是食入79（79％），然后是吸入和皮肤吸收21（21％）。全部（100％）患者均表现为高流涎，减数分裂，喘息和精神状态低下，随后为流泪90（90％），心动过缓58（58％），低血压76（76％），胸80（80％），呕吐69（69％），腹部绞痛40（80％）。观察到呼吸衰竭42例（42％），败血症5例（5％），癫痫9例（9％），肺水肿19例（19％）和ARDS 10例（10％）。 40名（40％）患者在正性肌力支持下进行了机械通气。平均住院时间为4.5天±2.5天（范围3-22天）。在100名患者中，有82名（82％）存活，死亡率为18名（18％）。死亡原因主要是由于呼吸衰竭。结论：有机磷中毒导致的死亡率在我们这一地区极高。对临床特征的识别将使早期诊断变得容易。

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