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首页> 外文期刊>Patient Preference and Adherence >Factors influencing medication knowledge and beliefs on warfarin adherence among patients with atrial fibrillation in China
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Factors influencing medication knowledge and beliefs on warfarin adherence among patients with atrial fibrillation in China

机译：中国房颤患者用药知识和对华法林依从性的信念影响因素

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Objectives: Warfarin is often used for ischemic stroke prevention in patients with atrial fibrillation (AF), but the factors affecting patient adherence to warfarin therapy have not been fully understood. Methods: A cross-sectional survey was conducted in AF patients undergoing warfarin therapy at least 6 months prior to the study. The clinical data collected using questionnaires by phone interviews included the following: 1) self-reported adherence measured by the Morisky Medication Adherence Scale-8?; 2) beliefs about medicines surveyed by Beliefs about Medicines Questionnaire (BMQ); and 3) drug knowledge as measured by the Warfarin Related Knowledge Test (WRKT). Demographic and clinical factors associated with warfarin adherence were identified using a logistic regression model. Results: Two hundred eighty-eight patients completed the survey and 93 (32.3%) of them were classified as nonadherent (Morisky Medication Adherence Scale-8 score <6). Major factors predicting warfarin adherence included age, cardiovascular disorders, WRKT, and BMQ; WRKT and BMQ were independently correlated with adherence to warfarin therapy by multivariate logistic regression analysis. Adherents were more likely to have greater knowledge scores and stronger beliefs in the necessity of their specific medications ([odds ratio {OR} =1.81, 95% confidence interval {CI} =1.51–2.15] and [OR =1.17, 95% CI =1.06–1.29], respectively). Patients with greater concerns about adverse reactions and more negative views of general harm were more likely to be nonadherent ([OR =0.76, 95% CI =0.69–0.84] and [OR =0.82, 95% CI =0.73–0.92], respectively). Conclusion: BMK and WRKT are related with patient behavior toward warfarin adherence. BMQ can be applied to identify patients at increased risk of nonadherence.
机译：目的：华法林常用于房颤（AF）患者的缺血性卒中的预防，但影响患者坚持华法林治疗依从性的因素尚未完全了解。方法：在研究前至少六个月对接受华法林治疗的房颤患者进行横断面调查。通过电话访谈使用问卷调查收集的临床数据包括：1）通过Morisky药物依从性量表8 ？测量的自我报告依从性; 2）《药品信念调查表》（BMQ）所调查的药品信念; 3）通过华法林相关知识测验（WRKT）衡量的药物知识。使用逻辑回归模型确定与华法林依从性相关的人口统计学和临床​​因素。结果：288位患者完成了调查，其中93位（32.3％）被归为非依从性（Morisky药物依从性评分表8得分<6）。预测华法林依从性的主要因素包括年龄，心血管疾病，WRKT和BMQ。通过多因素logistic回归分析，WRKT和BMQ与华法林治疗依从性独立相关。依从者更有可能对自己的特定药物有更高的知识得分和更强的信念（[比值比{OR} = 1.81，95％置信区间{CI} = 1.51-2.15]和[OR = 1.17，95％CI = 1.06-1.29]）。对不良反应更加担忧并且对一般伤害的看法更消极的患者更有可能是非依从性的（分别为[OR = 0.76，95％CI = 0.69-0.84]和[OR = 0.82，95％CI = 0.73-0.92] ）。结论：BMK和WRKT与患者对华法林依从性的行为有关。 BMQ可以用于识别不依从风险增加的患者。

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