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首页> 外文期刊>Pathology Research International >Placental Vascular Obstructive Lesions: Risk Factor for Developing Necrotizing Enterocolitis
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Placental Vascular Obstructive Lesions: Risk Factor for Developing Necrotizing Enterocolitis

机译：胎盘血管阻塞性病变：发展为坏死性小肠结肠炎的危险因素

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Necrotizing enterocolitis (NEC) is a severe neonatal disease affecting particularly preterm infants. Its exact pathogenesis still remains unknown. In this study, we have compared the prevalence of vascular obstructive lesions in placentae of premature newborns which developed NEC and of a control group. We further compared separately the findings of placentae of infants of less than 30 weeks of gestation, the age group in which NEC occurs most frequently. We found signs of fetal vascular obstructive lesions in 65% of the placentae of preterm patients developing NEC, compared to only 17% of the placentae of preterm patients in the control group. In the age groups below 30 weeks of gestation, 58.5% of placentae of later NEC patients presented such lesions compared to 24.5% in the control group. The significant difference between NEC and control group suggests a strong association between fetal vascular obstructive lesions and NEC. Therefore, we propose that fetal vascular obstructive lesions might be considered as a risk factor for the development of NEC in premature infants.
机译：坏死性小肠结肠炎（NEC）是一种严重的新生儿疾病，尤其影响早产儿。其确切的发病机理仍然未知。在这项研究中，我们比较了患有NEC的早产新生儿和对照组胎盘的血管阻塞性病变的患病率。我们进一步分别比较了妊娠少于30周（NEC最常出现的年龄组）的婴儿胎盘的发现。我们发现，发生NEC的早产儿胎盘中有65％的胎儿血管阻塞性病变的迹象，而对照组中只有17％的早产儿胎盘中有胎儿血管阻塞的迹象。在妊娠30周以下的年龄组中，晚期NEC患者的胎盘有58.5％出现了这种病变，而对照组为24.5％。 NEC与对照组之间的显着差异表明胎儿血管阻塞性病变与NEC之间有很强的关联。因此，我们建议将胎儿血管阻塞性病变视为早产儿NEC发生的危险因素。

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