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首页> 外文期刊>Patient Preference and Adherence >Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
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Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain

机译：患者和风湿病学家对西班牙用于治疗风湿病的生物制剂特性的偏爱

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Purpose: To define importance values assigned to attributes of biological agents (BAs) by Spanish patients with rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and rheumatologists. Patients and methods: This was an observational, cross-sectional design based upon a rank-based full-profile conjoint analysis. A literature review and four focus groups were undertaken to identify attributes and levels. An orthogonal matrix, combining the selected levels of attributes, was used to define scenarios. Participants ranked eight scenarios from 1 (most preferred) to 8?(least preferred). The relative importance (RI) of attributes was calculated. Multivariate regression analysis was performed to identify the characteristics that influenced the values of RI. A total of 488 patients (male 50.9%, mean age 50.6 [standard deviation {SD} 12.06] years, rheumatoid arthritis 33.8%, ankylosing spondylitis 32.4%, psoriatic arthritis 33.8%; mean time since diagnosis 12.6?[SD 8.2] years) and 136 rheumatologists (male 50.4%, mean age 46.4 [SD?9.1] years, mean time of practice 16.7 [SD 8.8] years) participated. Results: The ideal BAs for patients and physicians, respectively, should allow pain relief and improvement of functional capacity (RI 39% and 44.7%), with low risk of adverse events (RI?24.9% and 30.5%), a long time prior to perceiving the need for a new dose (RI 16.4% and 12.4%), and self-administration at home (RI 19.7% and 12.5%), as identified through their preferences. Conclusion: Although efficacy and safety are paramount for patients and rheumatologists to make a choice regarding BAs, the need for a low frequency of administration and the administration method also play a role as preference attributes for BAs.
机译：目的：定义由风湿病（类风湿关节炎，强直性脊柱炎和银屑病关节炎）的西班牙患者和风湿病学家分配给生物因子（BAs）属性的重要性值。患者和方法：这是基于基于等级的全轮廓联合分析的观察性横断面设计。进行了文献回顾和四个焦点小组来确定属性和水平。正交矩阵结合了选定的属性级别，用于定义方案。参与者对8种情况进行了排序，从1（最喜欢）到8（最不喜欢）。计算属性的相对重要性（RI）。进行多元回归分析以鉴定影响RI值的特征。共有488位患者（男性50.9％，平均年龄50.6 [标准差{SD} 12.06]年，类风湿关节炎33.8％，强直性脊柱炎32.4％，银屑病关节炎33.8％;自诊断以来的平均时间为12.6？[SD 8.2]年）。共有136名风湿病学家（男性50.4％，平均年龄46.4 [SD？9.1]岁，平均执业时间16.7 [SD 8.8]年）。结果：对于患者和医生而言，理想的BA应当能够长期缓解疼痛并改善功能能力（RI 39％和44.7％），并且不良事件风险较低（RI≥24.9％和30.5％）。根据他们的喜好确定需要新剂量（RI 16.4％和12.4％）以及在家自我管理（RI 19.7％和12.5％）。结论：尽管疗效和安全性对于患者和风湿病医师选择BAs至关重要，但是低频率的给药需求和给药方法也成为BAs的优先属性。

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