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首页> 外文期刊>Patient Preference and Adherence >Patients’, physicians’, nurses’, and pharmacists’ preferences on the characteristics of biologic agents used in the treatment of rheumatic diseases
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Patients’, physicians’, nurses’, and pharmacists’ preferences on the characteristics of biologic agents used in the treatment of rheumatic diseases

机译：患者，医师，护士和药剂师对风湿病治疗中使用的生物制剂特性的偏爱

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Objective: To estimate preferences in relevant treatment characteristics evaluated by different groups involved in the management of patients with rheumatic diseases. Subjects and methods: We surveyed patients with rheumatic diseases, and rheumatologists, nurses, and pharmacists with experience in treatment with/provision of biologic drugs for these patients. Through a discrete choice experiment, participants evaluated 16 possible scenarios in which pairs of similarly efficacious treatments were described with six characteristics: 1) frequency of administration; 2) mode and place of administration; 3) manner, helpfulness, efficiency, and courtesy of health personnel; 4) frequency of reactions at the site of drug administration; 5) severity of generalized undesired/allergic reactions; and 6) additional cost. The direction and strength of preferences toward each characteristic level and the relative importance of each characteristic were estimated through a random-effects conditional logistic regression model. Results: In total, 513 patients, 110 rheumatologists, 51 nurses, and 46 pharmacists from 30 centers in Italy participated. Characteristics 3, 4, and 6 were the most important for every subgroup; 1 was least important for patients and rheumatologists, 2 was least important for pharmacists, and 2 and 5 were least important for nurses. For characteristic 2, pharmacists preferred subcutaneous self-injection with a syringe; nurses preferred assisted infusion at an infusion center close to the patient’s home; patients and rheumatologists preferred subcutaneous self-injection with a pen. Conclusion: The different preferences for some characteristics shown by the different groups can play an important role, together with purely clinical aspects, in the choice and consequent benefit of treatments, contributing also to a more satisfactory use of resources.
机译：目的：评估由风湿病患者管理的不同小组评估的相关治疗特征的偏好。主题和方法：我们调查了风湿病患者，以及风湿病学家，护士和药剂师，这些患者在治疗/提供生物药物方面经验丰富。通过离散选择实验，参与者评估了16种可能的情况，其中描述了具有六个特征的成对相似有效的治疗：1）给药频率; 2）管理方式和地点; 3）卫生人员的态度，帮助，效率和礼貌; 4）给药部位的反应频率; 5）普遍的不良/过敏反应的严重性;和6）额外费用。通过随机效应条件对数回归模型估算了偏好对每个特征水平的方向和强度以及每个特征的相对重要性。结果：来自意大利30个中心的513例患者，110名风湿病医生，51名护士和46名药剂师参加了研究。特征3、4和6对每个子组来说都是最重要的; 1对患者和风湿病医生最不重要，2对药剂师最不重要，2和5对护士最不重要。对于特征2，药剂师首选使用注射器进行皮下自我注射;护士更喜欢在患者家附近的输液中心进行辅助输液;患者和风湿病学家更喜欢用笔进行皮下自我注射。结论：不同人群对某些特征的不同偏爱，在纯粹的临床方面，在选择治疗和随之而来的治疗收益方面都可以发挥重要作用，也有助于更令人满意地利用资源。

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