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Sociodemographic and clinical predictors of compliance with antidepressants for depressive disorders: systematic review of observational studies

机译：抑郁症抗抑郁药依从性的社会人口统计学和临床​​预测指标：观察性研究的系统评价

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Background: The literature shows that compliance with antidepressant treatment is unsatisfactory. Several personal and disease-related variables have been shown to be related to compliance behavior. The objective of this study was to review the literature about sociodemographic and clinical predictors of compliance in patients with depressive disorders. Methods: The Medline, Embase, Cochrane Central, PsycInfo, and Cinahl databases were searched until May 2012. Studies that analyzed sociodemographic and clinical predictors or correlates of compliance in patients with depressive disorder were included. A quantitative synthesis was not performed because of the heterogeneity and availability of the data reported. For similar reasons, the results were not classified according to the different phases of treatment. The search was limited to studies published in English and Spanish. Results: Thirty-two studies fulfilled the inclusion criteria. The most consistent associations with compliance were found for age (older patients showed more compliance) and race (white patients were more likely to adhere to treatment than minority ethnic groups). Few studies assessed clinical factors, and the most plausible predictors of compliance were certain comorbidities and substance abuse. Severity of depression did not play an important role in predicting compliance. Conclusion: The impact of the variables studied on compliance behavior appeared to be inconsistent. Identifying potential predictors of compliance with antidepressant treatment is important, both for the routine practice of the mental health professional and for refining interventions to enhance adherence and target them to specific populations at risk of noncompliance.
机译：背景：文献表明抗抑郁药治疗依从性不佳。已经显示出一些与个人和疾病相关的变量与依从行为有关。这项研究的目的是回顾有关抑郁症患者的社会人口统计学和临床​​依从性的文献。方法：检索直到2012年5月的Medline，Embase，Cochrane Central，PsycInfo和Cinahl数据库。包括分析社会人口学和临床预测因素或抑郁症患者依从性的相关研究。由于所报告数据的异质性和可用性，未进行定量合成。出于类似原因，未根据治疗的不同阶段对结果进行分类。该搜索仅限于以英语和西班牙语发表的研究。结果：32项研究符合纳入标准。发现与依从性最一致的关联是年龄（老年患者显示出更多依从性）和种族（白人患者比少数族裔人群更愿意坚持治疗）。很少有研究评估临床因素，而最合理的依从性预测因素是某些合并症和药物滥用。抑郁的严重程度在预测依从性方面没有重要作用。结论：研究的变量对依从行为的影响似乎不一致。确定抗抑郁治疗依从性的潜在预测因素很重要，这对于精神卫生专业人员的常规实践以及完善干预措施以增强依从性并将其针对有违法风险的特定人群而言都是重要的。

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