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首页> 外文期刊>Pain Physician >Pulsed Radiofrequency to the Dorsal Root Ganglion in Acute Herpes Zoster and Postherpetic Neuralgia
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Pulsed Radiofrequency to the Dorsal Root Ganglion in Acute Herpes Zoster and Postherpetic Neuralgia

机译：脉冲射频至急性带状疱疹和带状疱疹后神经痛的背根神经节

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BACKGROUND: Latent varicella zoster virus reactivates mainly in sensory ganglia such as the dorsal root ganglion (DRG) or trigeminal ganglion. The DRG contains many receptor channels and is an important region for pain signal transduction. Sustained abnormal electrical activity to the spinal cord via the DRG in acute herpes zoster can result in neuropathic conditions such as postherpetic neuralgia (PHN). Although the efficacy of pulsed radiofrequency (PRF) application to the DRG in various pain conditions has been previously reported, the application of PRF to the DRG in patients with herpes zoster has not yet been studied.OBJECTIVES: The aim of the present study was to compare the clinical effects of PRF to the DRG in patients with herpes zoster to those of PRF to the DRG in patients with PHN.STUDY DESIGN: Retrospective comparative study.SETTING: University hospital pain center in Korea.METHODS: The medical records of 58 patients who underwent PRF to the DRG due to zoster related pain (herpes zoster or PHN) were retrospectively analyzed. Patients were divided into 2 groups according to the timing of PRF after zoster onset: an early PRF group (within 90 days) and a PHN PRF group (more than 90 days). The efficacy of PRF was assessed by a numeric rating scale (NRS) and by recording patient medication doses before PRF and at one week, 4 weeks, 8 weeks, and 12 weeks after PRF.RESULTS: Pain intensity was decreased after PRF in all participants. However, the degree of pain reduction was significantly higher in the early PRF group. Moreover, more patients discontinued their medication in the early PRF group, and the PRF success rate was also higher in the early PRF group.LIMITATIONS: The relatively small sample size from a single center, short duration of review of medical records, and the retrospective nature of the study.CONCLUSIONS: PRF to the DRG is a useful treatment for treatment-resistant cases of herpes zoster and PHN. Particularly in herpes zoster patients with intractable pain, application of PRF to the DRG should be considered for pain control and prevention of PHN.Key words: Pulsed radiofrequency, dorsal root ganglion, herpes zoster, postherpetic neuralgia
机译：背景：水痘带状疱疹潜伏病毒主要在感觉神经节（例如背根神经节（DRG）或三叉神经节）中重新激活。 DRG包含许多受体通道，是疼痛信号转导的重要区域。在急性带状疱疹中，通过DRG对脊髓的持续异常电活动可能导致神经性疾病，例如疱疹后神经痛（PHN）。尽管先前已经报道了在各种疼痛情况下将脉冲射频（PRF）应用于DRG的功效，但尚未研究将PRF应用于带状疱疹患者的DRG中。目的：本研究的目的是为了比较带状疱疹患者的PRF与DRG的临床效果与PHN患者的PRF与DRG的临床效果。研究设计：回顾性比较研究背景：韩国大学医院疼痛中心方法：58例患者的病历回顾性分析了由于带状疱疹相关性疼痛（带状疱疹或PHN）而对DRG进行了PRF的患者。根据带状疱疹发作后PRF的时间将患者分为两组：早期PRF组（90天以内）和PHN PRF组（90天以上）。通过数字评分量表（NRS）并通过记录PRF之前，PRF后1周，4周，8周和12周时患者的药物剂量来评估PRF的疗效。结果：所有参与者PRF后疼痛强度均降低。但是，早期PRF组的疼痛减轻程度明显更高。此外，在早期PRF组中有更多的患者停止用药，并且在PRF早期组中PRF成功率也更高。局限性：来自单个中心的样本量相对较小，病历审查时间短以及回顾性结论：DRG的PRF对于治疗带状疱疹和PHN耐药的病例是一种有用的治疗方法。尤其是对于顽固性带状疱疹患者，应考虑将PRF应用于DRG以控制疼痛和预防PHN。关键词：射频脉冲，背根神经节，带状疱疹，带状疱疹后神经痛

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