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Perceived medication benefits and their association with interest in using inhaled insulin in type 2 diabetes: a model of patients' cognitive framework

机译：在2型糖尿病中使用药物的认知益处及其与吸入胰岛素的关联：患者认知框架的模型

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Objective: To examine predictors of patient perceived relevance of different diabetes medication benefits, and to determine how medication benefit ratings of an inhaled insulin were associated with evaluation of, and interest in that inhaled insulin.Methods: The study was an Internet survey of a US sample (n = 1094) of adults with type 2 diabetes using different medication regimens. Patients were given a brief description of potential clinical benefits and administration procedures for the inhaled insulin described in this study (based on MannKind Corporation's Technosphere insulin). Measures included indicators of medication benefits, needs and relevance, benefit ratings and overall evaluation of the studied inhaled insulin relative to current medication, and interest in the study medication. Multivariate regression assessed significant (P?< 0.05) independent associations, controlling for demographic and disease characteristics.Results: Relevance of potential medication benefits (avoidance of hyperglycemia, hypoglycemia, weight gain, discomfort/inconvenience) was significantly associated with objective and subjective indicators of patients' needs. Most need indicators were associated only with the specific benefit to which they apply; concerns about weight and lifestyle were associated with multiple benefits. Ratings of the studied inhaled insulin for avoiding postprandial hyperglycemia and discomfort/inconvenience were associated with overall evaluation of and interest in the inhaled insulin described in this study; rating of this medication for avoiding weight gain was associated with overall evaluation ratings.Conclusions: Relevance of different potential benefits was based on objective and subjective indicators of need. Perceived efficacy of the inhaled insulin described in this study for avoiding postprandial hyperglycemia and discomfort/inconvenience were the benefits most strongly related to the evaluation of and interest in this medication.
机译：目的：检查患者对不同糖尿病药物获益的感知相关性的预测因素，并确定吸入胰岛素的药物获益评级与吸入胰岛素的评估和兴趣如何相关。方法：该研究是对美国的一项互联网调查不同药物治疗方案的2型糖尿病成年人样本（n = 1094）。为患者简要介绍了本研究中描述的吸入式胰岛素的潜在临床益处和给药方法（基于MannKind Corporation的Technosphere胰岛素）。措施包括药物益处，需要和相关性的指标，相对于当前药物的研究吸入胰岛素的益处等级和总体评估，以及对研究药物的兴趣。多因素回归评估显着（P <0.05）独立关联，控制人口统计学和疾病特征。结果：潜在用药益处（避免高血糖，低血糖，体重增加，不适/不便）的相关性与以下因素的客观和主观指标显着相关患者的需求。大多数需求指标仅与它们所适用的具体利益相关;对体重和生活方式的担忧与多种益处有关。为避免餐后高血糖和不适/不便所研究的吸入式胰岛素的等级与本研究中描述的吸入式胰岛素的总体评价和兴趣有关。该药物避免体重增加的等级与总体评估等级相关。结论：不同潜在益处的相关性基于需求的主观和主观指标。在这项研究中描述的吸入胰岛素避免餐后高血糖和不适/不便的感知功效是与对该药物的评估和兴趣最密切相关的益处。

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