...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Patient Preference and Adherence >The outcomes of intra-aortic balloon pump usage in patients with acute myocardial infarction: a comprehensive meta-analysis of 33 clinical trials and 18,889 patients
【24h】

The outcomes of intra-aortic balloon pump usage in patients with acute myocardial infarction: a comprehensive meta-analysis of 33 clinical trials and 18,889 patients

机译：急性心肌梗死患者使用主动脉内球囊泵的结果：33项临床试验和18889例患者的综合荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The effects of intra-aortic balloon pump (IABP) usage in patients with acute myocardial infarction remain controversial. This study sought to evaluate the outcomes of IABP usage in these patients. Methods: Medline, EMBASE, and other internet sources were searched for relevant clinical trials. The primary efficacy endpoints (in-hospital, midterm, and long-term mortality) and secondary endpoints (reinfarction, recurrent ischemia, and new heart failure in the hospital) as well as safety endpoints (severe bleeding requiring blood transfusion and stroke in-hospital) were subsequently analyzed. Results: Thirty-three clinical trials involving 18,889 patients were identified. The risk of long-term mortality in patients suffering from acute myocardial infarction was significantly decreased following IABP use (odds ratio [OR] 0.66, 95% confidence interval [CI]: 0.48–0.91, P =0.010). Both in-hospital and midterm mortality did not differ significantly between the IABP use group and no IABP use group (in-hospital: OR 0.87, 95% CI: 0.59–1.28, P =0.479; midterm: OR 1.12, 95% CI: 0.53–2.38, P =0.768). IABP insertion was not associated with the risk reduction of reinfarction, recurrent ischemia, or new heart failure. However, IABP use increased the risk of severe bleeding requiring blood transfusion (OR 2.05, 95% CI: 1.29–3.25, P =0.002) and stroke (OR 1.71, 95% CI: 1.04–2.82, P =0.035). In the thrombolytic therapy and cardiogenic shock subgroups, reduced mortality rates following IABP use were observed. Conclusion: IABP insertion is associated with feasible benefits with respect to long-term survival rates in patients suffering from acute myocardial infarction, particularly those suffering from cardiogenic shock and receiving thrombolytic therapy, but at the cost of higher incidence of severe bleeding and stroke.
机译：背景：急性心肌梗死患者使用主动脉内球囊泵（IABP）的效果仍存在争议。本研究试图评估这些患者使用IABP的结果。方法：搜索Medline，EMBASE和其他互联网资源以进行相关的临床试验。主要疗效终点（医院内，中期和长期死亡率）和次要终点（再梗塞，复发性缺血和医院新心力衰竭）以及安全终点（严重出血需要输血和中风） ）随后进行了分析。结果：确定了涉及18,889例患者的33项临床试验。使用IABP后，患有急性心肌梗死的患者的长期死亡风险显着降低（几率[OR] 0.66，95％置信区间[CI]：0.48-0.91，P = 0.010）。 IABP使用组和非IABP使用组之间的院内和中期死亡率均无显着差异（院内：OR 0.87，95％CI：0.59-1.28，P = 0.479;中期：OR 1.12，95％CI： 0.53–2.38，P = 0.768）。 IABP插入与降低再梗塞，复发性缺血或新心力衰竭的风险无关。但是，IABP的使用增加了发生严重出血的风险，需要输血（OR 2.05，95％CI：1.29–3.25，P = 0.002）和中风（OR 1.71，95％CI：1.04-2.82，P = 0.035）。在溶栓治疗和心源性休克亚组中，观察到使用IABP后死亡率降低。结论：对于急性心肌梗死的患者，特别是患有心源性休克并接受溶栓治疗的患者，IABP的插入对于长期生存率具有切实可行的益处，但代价是严重出血和中风的发生率较高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号