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Patient–doctor relationship and adherence to capecitabine in outpatients of a German comprehensive cancer center

机译:德国综合癌症中心门诊患者的医患关系和对卡培他滨的依从性

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Purpose: The prescribing of oral chemotherapy agents has introduced the new challenge of ensuring patients’ adherence to therapy. Aspects of a close patient–doctor relationship are reported to be correlated with adherence to oral anticancer drugs, but data on capecitabine are scarce. Patients and methods: Sixty-four outpatients with a diagnosis of cancer and prescribed capecitabine were recruited from a German Comprehensive Cancer Center. We used the Patient–Doctor Relationship Questionnaire (PDRQ-9), the Medical Adherence Rating Scale (MARS), the Beliefs about Medicines Questionnaire (BMQ), and the Satisfaction with Information about Medicines Scale (SIMS) to assess patients’ perceptions and behavior. Medical data were extracted from the charts. Results: Non-adherence was reported by 20% of the 64 participants. The perceived quality of the patient–doctor relationship was high in general, but it did not emerge as a predictor of adherence in our survey (odds ratio [OR]=0.915, P =0.162, 95% CI=0.808–1.036). However, beliefs about medicine (OR=1.268, P 0.002; 95% CI=1.090–1.475) as well as satisfaction with information about medicine (OR=1.252, P 0.040, 95% CI=1.010–1.551) were predictors of adherence and the quality of the patient–doctor relationship was correlated with both variables ( r =0.373, P =0.002 for SIMS sum score; r =0.263, P =0.036 for BMQ necessity/concern difference). Overall, adherence to capecitabine was high with a conviction that the therapy is necessary. However, concerns were expressed regarding the long-term effect of capecitabine use. Patients have unmet information needs regarding interactions of capecitabine with other medicines and the impairment of their intimate life. Conclusions: In order to ensure adherence to capecitabine, our results seem to encourage the default use of modern and perhaps more impersonal means of information brokerage (eg, email, internet). However, the contents of some of patients’ informational needs as well as the associations of patients’ beliefs and satisfaction about the information received suggest a benefit from a trustful patient–doctor relationship.
机译:目的:口服化学治疗药物的处方给确保患者坚持治疗带来了新挑战。据报道,密切的医患关系与口服抗癌药物的依从性有关,但卡培他滨的数据很少。患者和方法:从德国综合癌症中心招募了64位诊断出患有癌症并开具卡培他滨的门诊患者。我们使用了“医患关系问卷”(PDRQ-9),“医疗依从性量表”(MARS),“关于药物问卷的信念”(BMQ)和“对药物信息的满意度”量表(SIMS)来评估患者的知觉和行为。从图表中提取医疗数据。结果:64位参与者中有20%报告不遵守。总体而言,患者与医生之间的关系质量普遍很高,但在我们的调查中并没有作为依从性的预测指标(赔率[OR] = 0.915,P = 0.162,95%CI = 0.808–1.036)。但是,对医学的信念(OR = 1.268,P <0.002; 95%CI = 1.090-1.475)以及对医学信息的满意度(OR = 1.252,P <0.040,95%CI = 1.010-1.551)是以下因素的预测指标依从性和医患关系的质量与两个变量均相关(r = 0.373,SIMS总和评分为P = 0.002; r = 0.263,BMQ必要性/关注差异为p = 0.036)。总体而言,对卡培他滨的依从性很高,并认为该疗法是必要的。但是,对于卡培他滨的长期使用效果表示关注。患者对卡培他滨与其他药物的相互作用以及他们的私密生活受到损害的信息需求尚未得到满足。结论:为了确保遵守卡培他滨,我们的结果似乎鼓励默认使用现代的,也许是更非个人化的信息经纪手段(例如,电子邮件,互联网)。但是,某些患者信息需求的内容以及患者对所接收信息的信念和满意度的关联表明,患者与医生之间建立了信任关系是有益的。

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