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首页> 外文期刊>Patient Preference and Adherence >Impact of multidisciplinary collaborative pharmaceutical care on knowledge, adherence, and efficacy of hormone therapy in climacteric women
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Impact of multidisciplinary collaborative pharmaceutical care on knowledge, adherence, and efficacy of hormone therapy in climacteric women

机译：多学科协作药物治疗对更年期妇女激素治疗的知识，依从性和疗效的影响

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Background: The objective of this study was to evaluate the impact of pharmaceutical care on the knowledge, adherence, and efficacy of hormone therapy in climacteric women participated in multidisciplinary collaborative clinic, launched by Peking University First Hospital (Beijing, People’s Republic of China) in 2012. Methods: A total of 296 patients were recruited (intervention group n=150, control group n=146). The patients in the intervention group visited the multidisciplinary collaborative clinic for their initial hormone therapy, receiving individualized pharmaceutical care (PC), whereas the control group visited only the general clinic without PC. The pill count method, knowledge assessment questionnaire (Cronbach’s α=0.80), and the modified Kupperman Index were used to assess the knowledge, adherence, and efficacy at months 3, 6, and 12. Results: The intervention group, which received PC, showed significantly higher and better knowledge, adherence, and efficacy than the control group, demonstrating the effectiveness of the PC provided. The knowledge scores of the intervention and control groups at months 3, 6, and 12 were (73.12 vs 59.28), (77.63 vs 66.19), and (80.81 vs 66.64); the data for adherence were (90.97% vs 82.17%), (93.21% vs 87.79%), and (95.81% vs 93.38%); and the values of the modified Kupperman Index were (17.15 vs 24.05), (13.22 vs 22.01), and (12.21 vs 23.15), respectively. Conclusion: PC improved the knowledge, adherence, and efficacy of hormone therapy in climacteric women. Therefore, the multidisciplinary collaborative model investigated in our study should be advocated in other health care institutions for the benefit of more patients. Further large-sample and long-term studies should be conducted to evaluate the effects of PC on patient clinical outcomes, including its impact on the safety and efficacy of long-term use of hormone therapy, as well as the economic benefits.
机译：背景：本研究的目的是评估药物治疗对参加由北京大学第一医院（中国北京）开设的跨学科合作诊所的更年期妇女激素治疗的知识，依从性和疗效的影响。 2012年方法：共招募296例患者（干预组n = 150，对照组n = 146）。干预组中的患者前往多学科合作诊所进行初始激素治疗，接受个体化药物治疗（PC），而对照组仅访问没有PC的普通诊所。使用药丸计数法，知识评估问卷（Cronbach'sα= 0.80）和改良的Kupperman指数评估第3、6和12个月的知识，依从性和疗效。结果：干预组接受了PC，显示出比对照组高得多，更好的知识，依从性和功效，证明了所提供PC的有效性。干预组和对照组在第3、6和12个月的知识得分分别为（73.12 vs 59.28），（77.63 vs 66.19）和（80.81 vs 66.64）;依从性数据分别为（90.97％vs 82.17％），（93.21％vs 87.79％）和（95.81％vs 93.38％）;修正的Kupperman指数的值分别为（17.15 vs.24.05），（13.22 vs 22.01）和（12.21 vs 23.15）。结论：PC可改善更年期女性激素疗法的知识，依从性和疗效。因此，在我们的研究中研究的多学科协作模型应该在其他医疗机构中提倡，以使更多的患者受益。应进行进一步的大样本和长期研究，以评估PC对患者临床结局的影响，包括其对长期使用激素治疗的安全性和有效性以及经济收益的影响。

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