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Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome

机译：超重（肥胖）和体重正常的多囊卵巢综合征女性的生活质量

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Objective: Polycystic ovary syndrome (PCOS) is characterized by phenotypic heterogeneity and has a wide variety of consequences. Approximately half of women with PCOS are overweight or obese, and their obesity may be a contributing factor to PCOS pathogenesis through different mechanisms. The aim of this study was to evaluate if PCOS alone affects the patients’ quality of life and to what extent obesity contributes to worsen this disease. Design: To evaluate the impact of PCOS on health-related quality-of-life (HRQoL), 100 Mediterranean women with PCOS (group A), 50 with a body mass index (BMI) >25?kg/m2 (group A1) and 50 with BMI 2 (group A2), were recruited. They were evaluated with a specific combination of standardized psychometric questionnaires: the Symptom Checklist-90 Revised, the 36-Item Short-Form Health Survey, and the Polycystic Ovary Syndrome Questionnaire. The patients were compared with a normal-weight healthy control group of 40 subjects (group B). Another control group of 40 obese healthy women (group C) was used to make a comparison with PCOS obese patients (A1). Results: Our results showed a considerable worsening of HRQoL in PCOS patients (A) compared with controls (B). In addition, patients with PCOS and BMI >25 (A1) showed a significant and more marked reduction in scores, suggesting a lower quality of life, compared with controls (B) and with normal-weight PCOS patients (A2). Conclusion: PCOS is a complex disease that alone determines a deterioration of HRQoL. The innovative use of these psychometric questionnaires in this study, in particular the PCOS questionnaire, has highlighted that obesity has a negative effect on HRQoL. It follows that a weight decrease is associated to phenotypic spectrum improvement and relative decrement in psychological distress.
机译：目的：多囊卵巢综合征（PCOS）的特征在于表型异质性，并具有多种后果。大约一半的PCOS妇女超重或肥胖，其肥胖可能是通过不同机制导致PCOS发病的因素。这项研究的目的是评估仅PCOS是否会影响患者的生活质量，以及肥胖在多大程度上加剧了该病的恶化。设计：为了评估PCOS对健康相关的生活质量（HRQoL）的影响，共有100名地中海PCOS妇女（A组），50名体重指数（BMI）> 25？kg / m 2招募（A 1 组）和50个BMI 2 （A 2 组）。他们使用标准化的心理调查表的特定组合进行了评估：修订的症状清单90、36项简短健康调查和多囊卵巢综合症问卷。将患者与体重正常的健康对照组（40名受试者）进行比较（B组）。另一对照组为40名肥胖健康女性（C组），用于与PCOS肥胖患者（A 1 ）进行比较。结果：我们的结果显示，与对照组（B）相比，PCOS患者（A）的HRQoL显着恶化。此外，与对照组（B）和体重正常的PCOS相比，PCOS和BMI> 25（A 1 ）的患者得分显着降低，而且生活质量明显降低，这表明生活质量较低患者（A 2 ）。结论：PCOS是一种复杂的疾病，仅决定HRQoL的恶化。这些心理测量问卷在本研究中的创新使用，尤其是PCOS问卷，凸显了肥胖对HRQoL有负面影响。因此，体重减轻与表型谱的改善和心理困扰的相对减少有关。

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