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首页> 外文期刊>Patient Preference and Adherence >Internal consistency and item-total correlation of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adult people with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study
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Internal consistency and item-total correlation of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adult people with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study

机译：在美国成年血友病患者中，患者报告的结局手段和血友病关节健康评分v2.1的内部一致性和项目间相关性：疼痛，功能障碍和生活质量（P-FiQ）研究的结果

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Background: The Pain, Functional Impairment, and Quality of Life study was an observational, cross-sectional assessment of the impact of pain on functional impairment and quality of life in adult people with hemophilia (PWH) of any severity in the USA who experience joint pain and/or bleeding. Objective: To assess internal consistency (IC) and item-total correlation (ITC) of assessment tools used in the Pain, Functional Impairment, and Quality of Life study. Methods: Participants completed 5 patient-reported outcome instruments (-EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], International Physical Activity Questionnaire [IPAQ], Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL]) and underwent an optional physiotherapist-administered musculoskeletal exam (Hemophilia Joint Health Score v2.1) during routine visits. Reliability assessment included IC and ITC of each instrument. Results: A total of 381 adult PWH (median age, 34 years) were enrolled. Participants were predominantly whiteon-Hispanic (69.2%); 75% had congenital hemophilia A, and 70.5% had severe hemophilia. A total of 310 subjects reported bleeding within the past 6 months (mean [SD] number of bleeds, 7.1 [13.00]). IC was generally high across the instruments employed (Cronbach’s alpha 0.79–0.98) with the exception of HAL use of transportation (0.58) and IPAQ total physical activity (0.51). ITC was high (Pearson’s product-moment correlation coefficient >0.20) for all items except the “vigorous intensity activities” item of IPAQ, which was applicable to less than one-third of participants. The ITCs were generally highest in domains/scores that measured the functional consequences of hemophilic arthropathy on mobility and pain. Conclusion: The demonstrated reliability (IC/ITC) of the patient-reported outcome instruments and Hemophilia Joint Health Score v2.1 support a role for these instruments in evaluating adult PWH in US clinical and research settings.
机译：背景：疼痛，功能障碍和生活质量研究是一项观察性横断面评估，评估疼痛对美国经历任何严重程度的血友病（PWH）成年人的关节功能障碍和生活质量的影响疼痛和/或出血。目的：评估疼痛，​​功能障碍和生活质量研究中使用的评估工具的内部一致性（IC）和项目总体相关性（ITC）。方法：参与者完成了5例患者报告的结局工具（-EQ-5D-5L，具有视觉模拟量表，简短疼痛量表v2简表[BPI]，国际体力活动问卷[IPAQ]，简表36健康调查v2 [SF-36v2] ]和血友病活动列表[HAL]），并在常规访问期间接受可选的物理治疗师进行的肌肉骨骼检查（血友病联合健康评分v2.1）。可靠性评估包括每种仪器的IC和ITC。结果：总共招募了381名成人PWH（中位年龄为34岁）。参加者主要是白人/非西班牙裔（69.2％）;先天性血友病为75％，重度血友病为70.5％。共有310名受试者报告了过去6个月内的出血（平均[SD]出血数量，为7.1 [13.00]）。除所使用的HAL运输工具（0.58）和IPAQ总身体活动（0.51）外，所有使用的器械的IC值通常都很高（Cronbach's alpha 0.79-0.98）。除IPAQ的“剧烈活动”项目外，所有项目的ITC均为高（皮尔逊产品与产品相关系数> 0.20），这适用于不到三分之一的参与者。在衡量血友病性关节炎对活动性和疼痛的功能性后果的领域/分数中，ITC通常最高。结论：患者报告的结局工具和血友病联合健康评分v2.1的证实的可靠性（IC / ITC）支持了这些工具在美国临床和研究机构中评估成人PWH的作用。

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