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首页> 外文期刊>Patient Preference and Adherence >Patient-reported adherence to coprescribed proton pump inhibitor gastroprotection in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs
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Patient-reported adherence to coprescribed proton pump inhibitor gastroprotection in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs

机译：患者报告使用非甾体类抗炎药对骨关节炎，类风湿性关节炎和强直性脊柱炎患者使用共同处方的质子泵抑制剂胃保护

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Background: Patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS) are commonly treated with nonsteroidal anti-inflammatory drugs (NSAIDs), sometimes with a concomitant gastroprotective proton pump inhibitor (PPI). The present study examines real-life patient adherence to PPIs when coprescribed with NSAIDs. Methods: This retrospective medical record survey identified patients diagnosed with OA, RA, or AS who had PPIs coprescribed with NSAIDs for prevention of NSAID-associated gastrointestinal ulcers. Actual NSAID and PPI intake was retrospectively recorded using a self-reported questionnaire. Adherence to PPI treatment was assessed using descriptive statistics. Results: In total, 96 patients (69% female, mean age 67 years, 72% OA, 16% RA, 12% AS) were included. The mean patient-reported adherence to coprescribed PPIs was 73%–81%. The percentage of patients with a self-reported adherence of ≤80% was 26%. No predictive factors for low adherence could be identified.Conclusion: Despite doctors’ instructions to use PPIs concomitantly with NSAIDs, the mean patient-reported adherence to coprescribed PPIs in this population indicates a risk of a “gastroprotective treatment gap”. The patients’ adherence to gastroprotective PPIs for the prevention of NSAID-associated upper gastrointestinal ulcers can be improved.
机译：背景：患有骨关节炎（OA），类风湿性关节炎（RA）或强直性脊柱炎（AS）的患者通常使用非甾体抗炎药（NSAIDs）进行治疗，有时还应同时使用胃保护性质子泵抑制剂（PPI）。本研究检查了与NSAID共同处方时，现实生活中患者对PPI的依从性。方法：这项回顾性医疗记录调查确定了患有OA，RA或AS的患者，这些患者的PPI与NSAID共同处方，可预防NSAID相关的胃肠道溃疡。使用自我报告的问卷回顾性记录了实际的NSAID和PPI摄入量。使用描述性统计评估对PPI治疗的依从性。结果：总共纳入了96例患者（女性69％，平均年龄67岁，OA 72％，RA 16％，AS 12％）。患者报告的对共同处方PPI的依从性为73％–81％。自我报告的依从性≤80％的患者百分比为26％。结论：尽管医生指示将PPI与NSAID同时使用，但该人群中患者报告的共同处方PPI依从性平均表明存在“胃保护性治疗缺口”的风险。可以改善患者对预防NSAID相关的上消化道溃疡的胃保护性PPI的依从性。

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