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What are the preferences of health care professionals in Germany regarding fully liquid, ready-to-use hexavalent pediatric vaccine versus hexavalent pediatric vaccine that needs reconstitution?

机译:对于需要重新配制的全液体,即用型六价儿科疫苗与六价儿科疫苗,德国的医疗保健专业人员有何偏好?

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Abstract: Diphtheria, tetanus and acellular pertussis (DTaP) based combined vaccines have led to significant reduction in incidence of several serious pediatric infectious diseases. A new, fully liquid combined hexavalent vaccine has been introduced and has been shown to reduce administration time. This fully liquid vaccine may also be simpler to administer and could reduce handling errors. The present study was designed to understand the value that health care providers (HCPs) place on aspects of injection devices for combined hexavalent vaccine programs in Germany. A discrete choice experiment (DCE) was designed to elicit the views of HCPs regarding hexavalent vaccines. The key attributes of injection devices were identified through a focused literature search and interviews with HCPs. Five key attributes, each with two or three levels were described which included: type of device, experience of this hexavalent vaccine on the German market, preparation time, probability of handling errors, and dosage errors. Physicians (n=150) and nurses (n=150) who administered hexavalent vaccines in Germany completed the survey. Choice data were analyzed using the conditional logit procedure. All attributes were significant and important independent influences on physicians’ and nurses’ choices. Reducing any “probability of dosage errors” was the most important attribute. Both physicians and nurses had a strong preference to reduce preparation time. All other things equal both groups also significantly preferred a fully liquid hexavalent vaccine. They also preferred vaccines that had been on the market for a few years compared to ones that had not (especially the physicians). Additional analyses explored participants’ preferences in more detail through interaction terms. The DCE choice data provide useful insights into how HCPs view each aspect of the vaccination device. Overall, the HCPs preferred fully liquid vaccines. The survey also highlighted the importance of handling and dosage errors, reducing preparation time, and also experience of the HCPs with the use of a vaccine. The survey work included physicians and nurses and explored their views separately.
机译:摘要:基于白喉,破伤风和无细胞百日咳(DTaP)的联合疫苗已导致几种严重的小儿传染病的发病率大大降低。已经引入了一种新的,完全液态的混合六价疫苗,已证明可以减少给药时间。这种完全液态的疫苗也可能更易于管理,并且可以减少处理错误。本研究旨在了解德国医疗保健提供者(HCP)在注射剂方面的价值,该注射剂用于联合六价疫苗计划。设计了离散选择实验(DCE)以引起HCP关于六价疫苗的观点。通过有针对性的文献搜索和对HCP的采访来确定注射装置的关键属性。描述了五个关键属性,每个属性具有两个或三个级别,包括:设备类型,该六价疫苗在德国市场上的经验,制备时间,处理错误的可能性和剂量错误。在德国服用六价疫苗的内科医生(n = 150)和护士(n = 150)完成了调查。使用条件logit程序分析选择数据。所有属性对于医生和护士的选择都是重要且重要的独立影响。减少任何“剂量错误的可能性”是最重要的属性。医师和护士都强烈希望减少准备时间。所有其他条件均相等的两组同样也明显优选全液体六价疫苗。与未上市的疫苗(尤其是医生)相比,他们还更喜欢上市几年的疫苗。额外的分析通过互动术语更详细地探讨了参与者的偏好。 DCE选择数据可帮助您深入了解HCP如何查看疫苗接种设备的各个方面。总体而言,HCP首选全液体疫苗。该调查还强调了处理和剂量错误,减少准备时间以及使用疫苗的HCP经验的重要性。调查工作包括医师和护士,并分别探讨了他们的观点。

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