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Perspectives on reasons of medication nonadherence in psychiatric patients

机译：精神病患者药物不依从原因的观点

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Purpose: This study was carried out to evaluate factors resulting in medication nonadherence within 6 months before admission to the psychiatric service of our hospital for bipolar disorder, schizophrenia/schizoaffective disorder, depression, and other psychiatric diseases.Patients and methods: Two hundred and three patients admitted to the Psychiatry Service of the Medical Faculty were included in this study. Sociodemographic parameters and clinical findings within 6 months before admission and patients’ views on reasons of medication nonadherence were examined.Results: Patients were classified into four groups according to their diagnosis: bipolar disorder (n=68, 33.5%), schizophrenia/schizoaffective disorder (n=59, 29.1%), depression (n=39, 19.2%), and others (n=37, 18.2%). The ratio of medication nonadherence was higher in the bipolar disorder group when compared to the groups with schizophrenia/schizoaffective disorder, depression, and other disorders (12.1%, 18.2%, and 24.2% vs 45.5%); however, the ratio of medication nonadherence was similar in schizophrenia/schizoaffective disorder, depression, and the others group. In logistic regression analysis, irregular follow-up (odds ratio [OR]: 5.7; 95% confidence interval [CI]: 2.92–11.31) and diagnosis (OR: 1.5; 95% CI: 1.07–1.95) were determined to be important risk factors for medication nonadherence. The leading factors for medication nonadherence were: “not willing to use medication”, “not accepting the disease”, and “being disturbed by side effects” in the bipolar disorder group, “not accepting the disease” in the schizophrenia/schizoaffective disorder group, “feeling well” in the depression group, and “being disturbed by side effects” in the other diseases group.Conclusion: Medication nonadherence is an important problem in psychiatric patients and should be dealt with by taking into account the diagnosis, attendance to follow-up appointments, and the patient’s attitude. Ensuring regular attendance to follow-up appointments, adjusting the management plan according to the diagnosis, and improving their thoughts about resistance to medication can be beneficial in terms of medication adherence.
机译：目的：本研究旨在评估导致我院因双相情感障碍，精神分裂症/精神分裂性情感障碍，抑郁症和其他精神疾病而入院的精神病患者服药六个月内未坚持治疗的因素。患者和方法：203本研究包括入院医学院精神病学服务的患者。结果：根据患者的诊断将其分为四类：双相情感障碍（n = 68，33.5％），精神分裂症/精神分裂性情感障碍，分为四组。 （n = 59，29.1％），抑郁症（n = 39，19.2％）和其他（n = 37，18.2％）。与患有精神分裂症/精神分裂症，抑郁症和其他疾病的组相比，双相情感障碍组的药物非依从率更高（12.1％，18.2％和24.2％对45.5％）;然而，在精神分裂症/精神分裂症，抑郁症和其他人群中，药物不依从的比例相似。在逻辑回归分析中，确定不规律的随访（优势比[OR]：5.7; 95％置信区间[CI]：2.92-11.31）和诊断（OR：1.5; 95％CI：1.07-1.95）很重要药物不依从的危险因素。药物不依从的主要因素是：躁郁症患者中“不愿意使用药物”，“不接受疾病”和“被副作用所困扰”，精神分裂症/精神分裂症患者中的“不接受疾病” ，抑郁症组的“感觉良好”和其他疾病组的“被副作用所困扰”。结论：药物不依从性是精神病患者的重要问题，应通过诊断，出勤率加以处理预约，以及患者的态度。确保定期参加随访，根据诊断调整管理计划，以及改善他们对药物耐药性的看法，对药物依从性有好处。

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