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首页> 外文期刊>Pediatric Reports >Health and development of children born after assisted reproductive technology and sub-fertility compared to naturally conceived children: data from a national study
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Health and development of children born after assisted reproductive technology and sub-fertility compared to naturally conceived children: data from a national study

机译：与自然受孕儿童相比，辅助生殖技术和亚生育力后出生的儿童的健康和发展：一项国家研究的数据

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摘要

In a non-matched case-control study using data from two large national cohort studies, we investigated whether indicators of child health and development up to 7 years of age differ between children conceived using assisted reproductive technology (ART), children born after sub-fertility (more than 24 months of trying for conception) and other children. Information on ART use/sub-fertility was available for 23,649 children. There were 227 cases (children conceived through ART) and two control groups: 783 children born to sub-fertile couples, and 22,639 children born to couples with no fertility issues. In models adjusted for social and demographic factors there were significant differences between groups in rate of hospital admissions before the children were 9 months old (P=0.029), with the ART group showing higher rates of hospital admission than the no fertility issues control group, the sub-fertile control group being intermediate between the two. Children born after ART had comparable health and development beyond 9 months of age to their naturally conceived peers. This applied to the whole sample and to a sub-sample of children from deprived neighborhoods.
机译：在一项不匹配的病例对照研究中，我们使用了两项来自大型国家队列研究的数据，我们调查了使用辅助生殖技术（ART）孕育的儿童，分娩后出生的儿童与7岁以下儿童的健康状况和发育指标是否存在差异。生育能力（尝试怀孕超过24个月）和其他孩子。有23,649名儿童获得了抗逆转录病毒疗法使用/亚生育率的信息。有227例（通过抗逆转录病毒疗法受孕的孩子）和两个对照组：783例次生育夫妇所生的孩子和22639例没有生育问题的夫妇所生的孩子。在针对社会和人口因素调整的模型中，儿童在9个月大之前，各组之间的入院率存在显着差异（P = 0.029），ART组的住院率要高于无生育问题的对照组，亚生育力对照组在两者之间。接受抗逆转录病毒治疗后出生的孩子，其9个月以上的健康状况和发育状况与他们的自然同龄人相当。这适用于整个样本以及来自贫困社区的子样本。

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