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Towards a vaccine against pregnancy-associated malaria

机译：研发针对与妊娠相关的疟疾的疫苗

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The consequences of pregnancy-associated malaria on pregnant women (anaemia), their babies (birth weight reduction), and infants (increased morbidity and mortality) are well documented. Field observations during the last decade have underlined the key role of the interactions between P. falciparum variable surface antigens expressed on infected erythrocytes and a novel receptor: chondroitin sulfate A (CSA) for the placental sequestration of infected erythrocytes. Identification of a distinct P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant, VAR2CSA, as the dominant variant surface antigen and as a clinically important target for protective immune response to pregnancy-associated malaria has raised hope for developing a new preventive strategy based on inducing these immune responses by vaccination. However, despite particular structure and interclonal conservation of VAR2CSA among other PfEMP1, significant challenges still exist concerning the development of a VAR2CSA-based vaccine with profound efficacy.Key words: P. falciparum / malaria / pregnancy / vaccine
机译：怀孕相关的疟疾对孕妇（贫血），其婴儿（出生体重减轻）和婴儿（发病率和死亡率增加）的后果已得到充分证明。在过去十年中的现场观察强调了在感染的红细胞上表达的恶性疟原虫可变表面抗原与一种新型受体：硫酸软骨素A（CSA）在胎盘隔离感染的红细胞之间相互作用的关键作用。鉴定出独特的恶性疟原虫红细胞膜蛋白1（PfEMP1）变体VAR2CSA作为显性变体表面抗原，并作为针对与妊娠相关的疟疾的保护性免疫应答的重要临床靶标，为开发新的预防策略提供了希望通过疫苗诱导这些免疫反应。然而，尽管VAR2CSA在其他PfEMP1中具有特殊的结构和克隆间保守性，但在开发具有深远功效的基于VAR2CSA的疫苗方面仍然存在重大挑战。关键词：恶性疟原虫/疟疾/妊娠/疫苗

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