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Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases

机译：白藜芦醇：一种抗衰老药物，在疾病治疗中具有潜在的治疗应用

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The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.
机译：防止衰老是生物医学中最引人入胜的领域之一。开发有效的预防衰老药物的第一步是了解负责细胞衰老过程的生化途径。在这种情况下，显然自由基在衰老过程中起着关键作用。但是，近年来，已证明称为瑟土因的酶家族，特别是situin 1（SIRT1）具有抗衰老作用。因此，天然化合物白藜芦醇是显示出非常强的SIRT1活化并且还显示出抗氧化作用的天然化合物。通过激活sirtuin 1，白藜芦醇可以调节许多蛋白质的活性，包括过氧化物酶体增殖物激活受体共激活因子1α（PGC-1 alpha），FOXO家族，Akt（蛋白激酶B）和NFκβ。在本综述中，我们建议白藜芦醇由于其抗氧化特性和沉默调节蛋白的活化作用，可能成为预防衰老和治疗多种疾病的潜在药物。

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