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Polypharmacy and Psychological Distress May Be Associated in African American Adults

机译：非洲裔美国成年人中可能存在多种药房和心理困扰

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Background: Compared to Whites, African Americans are at a higher risk of multiple chronic conditions, which places them at a higher risk of polypharmacy. Few national studies, however, have tested whether polypharmacy is associated with psychological distress—the net of socioeconomic status, health status, and stress—in African Americans. Aims: In a national sample of African Americans in the US, this study investigated the association between polypharmacy and psychological distress. Methods: The National Survey of American Life (NSAL, 2003) included 3570 African American adults who were 18 years or over. This number was composed of 2299 women and 1271 men. Polypharmacy (using ≥ 5 medications) and hyper-polypharmacy (using ≥ 10 medications) were the independent variables. Psychological distress was the dependent variable. Age, gender, socioeconomic status (education attainment, income, employment, and marital status), health care access (insurance status and usual place of care), and health status (multimorbidity and psychiatric disorders) were the covariates. Linear multivariable regression was applied to perform the data analysis. Results: Both polypharmacy and hyper-polypharmacy were associated with psychological distress. This association was significant after controlling for all the covariates. Conclusions: African Americans with polypharmacy, particularly those with hyper-polypharmacy, are experiencing higher levels of psychological distress, which itself is a known risk factor for poor adherence to medications. There is a need for a comprehensive evaluation of medications as well as screening for psychopathology in African Americans with multiple medical conditions.
机译：背景：与白人相比，非裔美国人面临多种慢性病的风险较高，这使他们处于多药店的较高风险。但是，很少有国家研究测试非裔美国人是否将多元药业与心理困扰相关联（社会经济地位，健康状况和压力的净值）。目的：在一项针对美国非裔美国人的全国性样本中，这项研究调查了多元药房与心理困扰之间的关联。方法：美国国家生命调查（NSAL，2003）包括3570名18岁以上的非洲裔美国人。这个数字是由2299名女性和1271名男性组成。自变量是多药房（使用≥5种药物）和高药房（使用≥10种药物）。心理困扰是因变量。年龄，性别，社会经济状况（受教育程度，收入，就业和婚姻状况），医疗保健可及性（保险状况和通常的护理地点）和健康状况（多发病和精神病）是协变量。应用线性多变量回归进行数据分析。结果：多元药房和超多元药房均与心理困扰有关。在控制所有协变量后，这种关联是显着的。结论：拥有多药店的非裔美国人，特别是那些拥有超多药店的非裔美国人正遭受更高的心理困扰，这本身就是人们对药物依从性差的已知危险因素。需要对具有多种医疗状况的非洲裔美国人进行药物的综合评估以及心理病理学筛查。

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