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Estonian folk traditional experiences on natural anticancer remedies: From past to the future

机译：爱沙尼亚民间传统抗癌疗法的传统经验：从过去到未来

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants.Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years.Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA ( http://herba.folklore.ee/ ), containing altogether more than 30?000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.Results and conclusion: As a result, 44 different plants with potential anticancer properties were elicited, 5 of which [Angelica sylvestris L. (Apiaceae), Anthemis tinctoria L. (Asteraceae), Pinus sylvestris L. (Pinaceae), Sorbus aucuparia L. (Rosaceae), and Prunus padus L. (Rosaceae)] have not been previously described with respect to their tumoricidal activities in the scientific literature, suggesting thus the potential herbal materials for further investigations of natural anticancer compounds.
机译：背景：尽管在诊断和治疗方面取得了进步，但全世界的癌症负担仍在增加。当前化学疗法对正常细胞的毒性及其对肿瘤细胞的抗性凸显了对具有最小不良副作用的新药物的迫切需求。天然抗癌药的使用已进入癌症研究领域，并且正在加大力度从药用植物中分离出生物活性产物。目的：为寻找具有潜在细胞毒活性的植物，民族药理学知识可以做出巨大贡献。因此，这篇评论的重点是爱沙尼亚人在过去近150年的时间里传统上用于癌症治疗的自然疗法。方法：两个庞大的数据库，第一个存储在爱沙尼亚民俗档案中，第二个存储在爱沙尼亚民俗档案中。系统地审查了电子数据库HERBA（http://herba.folklore.ee/），该数据库共收录了30,000多种民族医学文本，以汇编有关自然疗法的爱沙尼亚民间传统经验的数据。结果与结论：结果诱导出44种具有潜在抗癌特性的植物，其中5种为[当归，Ang科，菊科，菊科，毛or科，蔷薇科和李属。 L.（Rosaceae）]在其科学文献中尚未对其杀虫活性进行过描述，因此暗示了潜在的草药材料可用于进一步研究天然抗癌化合物。

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