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首页> 外文期刊>Pharmacognosy Research >A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn. on experimental animal models
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A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn. on experimental animal models

机译：番石榴叶抗炎作用的研究。在实验动物模型上

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Introduction:The aim is to study the anti-inflammatory effect of the ethanolic extract of the leaves of Psidium guajava(PGE) on experimental animal models.Materials and Methods:Fresh leaves were collected, air-dried, powdered, and percolated in 95% ethanol. Acute toxicity test was done according to OECD guidelines. Four groups of animals of either sex, weighing 150–200g of the species Rattus norvegicus were taken for the study (n = 6). Group A was taken as control (3% gum acacia in 10 mL/kg body weight), Group B as test group (PGE 250 mg/kg body weight), Group C as test group (PGE 500 mg/kg body weight), and Group D as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema, subacute inflammation by Granuloma pouch method, and chronic inflammation by Freund’s adjuvant-induced arthritis method. Statistical analysis was done by one-way analysis of variance followed by multiple comparison tests.Results:In acute inflammation, there was significant inhibition of paw edema in Groups B, C, and D in comparison with Group A (P < 0.05). In subacute inflammation, there was significant inhibition of exudate formation in Groups B, C, and D in comparison to Group A (P < 0.05). In chronic inflammation, there was significant inhibition of paw edema and inhibition of weight reduction in Groups B, C, and D compared with Group A. Downregulation of arthritis index was also significant in Groups B, C, and D in comparison with Group A (P < 0.05).Conclusion:The ethanolic extract of PGE has significant anti-inflammatory activity.
机译：简介：目的是研究番石榴叶乙醇提取物对实验动物模型的抗炎作用。材料与方法：收集新鲜叶片，风干，粉化和浸透95％。乙醇。急性毒性试验是根据OECD指南进行的。取四组动物，每只动物的重量为150–200g褐家鼠物种（n = 6）。 A组为对照组（3％阿拉伯树胶，10 mL / kg体重），B组为测试组（PGE 250 mg / kg体重），C组为测试组（PGE 500 mg / kg体重）， D组为标准（阿司匹林100 mg / kg体重）。用角叉菜胶诱导的大鼠爪水肿研究了这些动物的急性炎症，用肉芽肿囊法研究了亚急性炎症，并用弗氏佐剂诱导的关节炎方法研究了慢性炎症。结果：在急性炎症中，与A组相比，B，C和D组的足爪水肿得到了显着抑制（P <0.05）。在亚急性炎症中，与A组相比，B，C和D组明显抑制了渗出液的形成（P <0.05）。与A组相比，在慢性炎症中，B，C和D组的爪水肿得到了显着抑制，B，C和D组的体重减轻得到了抑制。与A组相比，B，C和D组的关节炎指数下调也很明显（ P <0.05）。结论：PGE的乙醇提取物具有明显的抗炎活性。

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