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首页> 外文期刊>Pharmacognosy Research >Effects of the oral administration of nonpolar extract from Ardisia squamulosa Presl (Myrsinaceae) leaves on spermatogenesis in rats
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Effects of the oral administration of nonpolar extract from Ardisia squamulosa Presl (Myrsinaceae) leaves on spermatogenesis in rats

机译：口服扁桃叶非极性提取物对大鼠精子发生的影响

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Background:Several Ardisia species have been found to possess numerous bioactivities but their reproductive toxicity has been poorly explored. In the present study, the effects of the leaf hexane extract of Philippine indigenous Ardisia squamulosa on epididymal sperm count, %viability and %aberration of sperms and weights of seminal vesicle, cauda epididymis, and testes in addition to the weights of liver, kidney, and body were evaluated.Methods:The extracts at daily dose levels of 1, 10, and 100 mg/Kg BW in 10% polysorbate-80 in corn oil were administered by gavage for 8 successive days to 8-10 weeks old male SD rats and sacrificed after 9 days. Daily body weights and final organ weights were measured. Sperm from the cauda epididymis was extracted and measured according standard sperm parameters (sperm count, morphology, viability and membrane integrity).Results:Significant findings were the decline of left epididymal sperm count to testis weight ratio and increase in %sperm morphological aberration from both cauda epididymis obtained with the 10 mg/Kg BW dose.Conclusion:The hexane extract from Ardisia squamulosa had significant effect on sperm count but with negligible effect on sperm morphology and viability.
机译：背景：已发现几种Ardisia物种具有许多生物活性，但对其生殖毒性的研究却很少。在本研究中，菲律宾土著Ardisia squamulosa的叶己烷提取物对附睾精子数量，精子存活率和畸变率以及精囊，附睾和睾丸重量的影响，以及肝脏，肾脏，方法：连续饲喂8-10周龄的雄性SD大鼠，连续8天将玉米油中10％聚山梨酯-80中日剂量分别为1、10和100 mg / Kg BW的提取物给药8天。并在9天后牺牲。测量每日体重和最终器官重量。根据标准的精子参数（精子数量，形态，生存力和膜完整性）提取和测量马尾附睾的精子。结果：重要发现是左附睾精子数量相对于睾丸重量比的下降以及两者精子形态畸变率的增加。结论：10mg / Kg BW剂量的附睾马尾附睾。结论：南瓜子中的己烷提取物对精子数量有显着影响，但对精子形态和活力的影响可忽略不计。

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