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Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats

机译：对香豆酸和柚皮苷对阿霉素诱导的大鼠心脏毒性的联合作用

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Background:Doxorubicin (DOX) is the most active cytotoxic agents having efficacy in malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. This study is based on the possible protective effects of combination of p-coumaric acid (PC) and naringenin (NR) on DOX induced cardiac toxicity in male Swiss albino rats.Methods:Total nine groups of Swiss albino rats were used, Group I (vehicle control) receive saline solution daily and Group II (disease control) receive saline solution daily up to 29th day and at 30th day a single dose of DOX (15 mg/kg i.p.) is given. PC alone (100 mg/kg/day p.o.) and (200 mg/kg/day p.o.) also NR alone (15 mg/kg/day) orally administer for 30 days. Similarly a standard drug Vit. E (100 mg/kg/day) administers alone for 30 days. Group PC/DOX and PC and NR/DOX receive PC (200 mg/kg/day) and combine PC (200 mg/kg/day).Results:Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including increase in MDA level and decrease SOD, CAT & GSH level but prior administration of combination of PC & NR ahead of doxorubicin challenge ameliorated all these biochemical markers.Conclusion:The study proves the beneficial effects of combination of PC and NR in protecting animal against DOX induced cardiotoxicity.
机译：背景：阿霉素（DOX）是最活跃的细胞毒性药物，无论是单独使用还是与其他杀细胞剂联合使用都具有治疗恶性肿瘤的功效。心脏毒性已排除了蒽环类药物的临床实用性。已经尝试了许多治疗干预措施来改善药物的治疗效果。这项研究是基于对香豆酸（PC）和柚皮素（NR）联合可能对DOX诱导的瑞士白化病雄性大鼠心脏毒性的保护作用。方法：共使用九组瑞士白化病大鼠，第一组（媒介物对照）每天接受盐溶液，第二组（疾病对照）直到29天每天接受盐溶液，在30天时接受单剂量的DOX（15 mg / kg ip）。口服单独PC（100 mg / kg /天p.o.）和（200 mg / kg / day p.o.）也单独NR（15 mg / kg / day p.o.）口服30天。同样是标准药物Vit。 E（100 mg / kg /天）单独给药30天。 PC / DOX组和PC和NR / DOX组接受PC（200 mg / kg /天）并联合PC（200 mg / kg /天）。结果：阿霉素诱导的心脏毒性具有明显的生化改变，包括MDA水平升高和降低SOD，CAT和GSH水平升高，但在阿霉素攻击前先给予PC和NR可以改善所有这些生化指标。结论：本研究证明了PC和NR组合在保护动物免受DOX诱导的心脏毒性方面的有益作用。

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