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首页> 外文期刊>Physiological Reports >Muscle ion transporters and antioxidative proteins have different adaptive potential in arm than in leg skeletal muscle with exercise training
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Muscle ion transporters and antioxidative proteins have different adaptive potential in arm than in leg skeletal muscle with exercise training

机译：进行运动训练时，手臂的肌肉离子转运蛋白和抗氧化蛋白的适应能力与腿部骨骼肌不同

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It was evaluated whether upper?￠????body compared to lower?￠????body musculature exhibits a different phenotype in relation to capacity for handling reactive oxygen species (ROS), H + , La ?￠???? , Na + , K + and also whether it differs in adaptive potential to exercise training. Eighty?￠????three sedentary premenopausal women aged 45???????±????6????years (mean???????±????SD) were randomized into a high?￠????intensity intermittent swimming group (HIS, n???? = ???? 21), a moderate?￠????intensity swimming group (MOS, n???? = ???? 21), a soccer group (SOC, n???? = ???? 21), or a control group (CON, n???? = ???? 20). Intervention groups completed three weekly training sessions for 15????weeks, and pre?￠???? and postintervention biopsies were obtained from deltoideus and vastus lateralis muscle. Before training, monocarboxylate transporter 4 (MCT4), Na + /K + pump ???± 2 , and superoxide dismutase 2 (SOD2) expressions were lower ( P???? < ???? 0.05) in m .????deltoideus than in m .????vastus lateralis, whereas deltoid had higher ( P???? < ???? 0.05) Na + /H + exchanger 1 (NHE1) expression. As a result of training, Na + /K + pump ???± 2 isoform expression was elevated only in deltoideus muscle, while upregulation ( P???? < ???? 0.05) of the ???± 1 and ???2 1 subunits, phospholemman (FXYD1), NHE1, and superoxide dismutase 1 expression occurred exclusively in vastus lateralis muscle. The increased ( P???? < ???? 0.05) expression of MCT4 and SOD2 in deltoid muscle after HIS and vastus lateralis muscle after SOC were similar. In conclusion, arm musculature displays lower basal ROS, La ?￠???? , K + handling capability but higher Na + ?￠????dependent H + extrusion capacity than leg musculature. Training?￠????induced changes in the ion?￠????transporting and antioxidant proteins clearly differed between muscle groups.
机译：评估上肢身体与下肢身体肌肉相对于处理活性氧（ROS），H +，La的能力是否表现出不同的表型。 ，Na +，K +以及运动训练的适应能力是否有所不同。将80名三名45岁的久坐的绝经前女性（平均SD）平均分为6岁。高强度间歇游泳组（HIS，n≥21＝ 21），中等强度间歇游泳组（MOS，n ＝≥21）。 Δ21），足球组（SOC，n≥21）或对照组（CON，n≥20）。干预小组完成了三个每周的培训课程，为期15周，每周15周。干预后活检取自三角肌和股外侧肌。在训练之前，单羧酸盐转运蛋白4（MCT4），Na + / K +泵±2和超氧化物歧化酶2（SOD2）的表达在m时较低（P <0.01≤0.05）。 δ理想肌比侧位输卵管中的δ富集，而三角肌具有更高的（P≤0.05）Na + / H +交换子1（NHE1）表达。训练的结果是，仅在三角肌中Na + / K +泵的±2同工型表达升高，而±1和β的上调（P ＜0.05 ＜＜ 0.05）。 2 1个亚基，磷酸化lemman（FXYD1），NHE1和超氧化物歧化酶1表达仅发生在股外侧肌中。 HIS后三角肌中MCT4和SOD2的表达增加（P≤0.05<0.05），SOC后，股外侧肌的MCT4和SOD2表达增加。总之，手臂的肌肉组织显示出较低的基础ROS，La？￠ ???? ，K +处理能力，但比腿部肌肉组织具有更高的Na +依赖性H +挤压能力。训练在肌肉群之间引起的离子运输和抗氧化蛋白变化明显不同。

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