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Anti-Leishmania Activity of Osthole

机译：臭虫的抗利什曼原虫活性

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Background: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens. Objective: In this study in vitro and in vivo antileishmanial activities of osthole, a natural coumarin known to possess antibacterial and parasiticidal activities are evaluated. Materials and Methods: Leishmania major infected J774.A1 macrophages were treated with increasing concentrations of osthole. CL lesions of BALB/c mice were treated topically with 0.2% osthole. Results: Osthole exhibited dose-dependent leishmanicidal activity against intracellular amastigotes with IC50 value of 14.95 μg/ml. Treatment of CL lesions in BALB/c mice with osthole significantly declined lesion progression compared to untreated mice ( P < 0.05), however did not result in recovery. Conclusion: Osthole demonstrated remarkable leishmanicidal activity in vitro . Higher concentrations of osthole may demonstrate the therapeutic property in vivo . SUMMARY In vitro and in vivo antileishmanial activities of osthole, a pernylated coumarin extracted from Prangos asperula Boiss., are studied against Leishmania major .
机译：背景：皮肤利什曼病（CL）的治疗有时对五价锑具有高度耐药性，五价锑是CL药物治疗的金标准。由于没有有效的疫苗，因此可以使用天然的抗衰老产品作为补充治疗剂来改善目前的治疗方案。目的：在这项研究中，对osthole的体外和体内排虫活性进行了评估，对一种已知具有抗菌和杀虫活性的天然香豆素进行了评估。材料和方法：利什曼原虫主要感染的J774.A1巨噬细胞用升高的粪便浓度进行处理。 BALB / c小鼠的CL病变局部用0.2％蛇床子素治疗。结果：Osthole对细胞内变形虫具有剂量依赖性的杀菌作用，IC 50 值为14.95μg/ ml。与未经治疗的小鼠相比，用osthole处理BALB / c小鼠的CL病变明显降低了病变进展（P <0.05），但是未导致恢复。结论：Osthole在体外显示出显着的杀菌作用。高浓度的蛇床子素可能证明在体内具有治疗作用。发明内容研究了从利什曼原虫中提取的从Prangos asperula Boiss。中提取的带烯丙基香豆素的臭虫的体外和体内抗菊苣活性。

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