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首页> 外文期刊>Pharmacognosy Research >Inhibition of Group IIA Secretory Phospholipase A2 and its Inflammatory Reactions in Mice by Ethanolic Extract of Andrographis paniculata, a Well-known Medicinal Food
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Inhibition of Group IIA Secretory Phospholipase A2 and its Inflammatory Reactions in Mice by Ethanolic Extract of Andrographis paniculata, a Well-known Medicinal Food

机译：著名药材穿心莲的乙醇提取物抑制IIA族分泌型磷脂酶A2及其在小鼠中的炎症反应

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Andrographis paniculata Nees is an important medicinal plant found in the tropical regions of the world, which has been traditionally used in Indian and Chinese medicinal systems. It is also used as medicinal food. A. paniculata is found to exhibit anti-inflammatory activities; however, its inhibitory potential on inflammatory Group IIA phospholipases A2 (PLA2) and its associated inflammatory reactions are not clearly understood. The aim of the present study is to evaluate the inhibitoryeutralizing potential of ethanolic extract of A. paniculata on the isolated inflammatory PLA2 (VRV-PL-VIIIa) from Daboii rusellii pulchella (belonging to Group IIA inflammatory secretory PLA2 [sPLA2]) and its associated edema-induced activities in Swiss albino mice. A. paniculata extract dose dependently inhibited the Group IIA sPLA2 enzymatic activity with an IC50 value of 10.3 ± 0.5 μg/ml. Further, the extract dose dependently inhibited the edema formation, when co-injected with enzyme indicating that a strong correlation exists between lipolytic and pro-inflammatory activities of the enzyme. In conclusion, results of this study shows that the ethanolic extract of A. paniculata effectively inhibits Group IIA sPLA2 and its associated inflammatory activities, which substantiate its anti-inflammatory properties. The results of the present study warranted further studies to develop bioactive compound (s) in ethanolic extract of A. paniculata as potent therapeutic agent (s) for inflammatory diseases. SUMMARY This study emphasis the anti-inflammatory effect of A. paniculata by inhibiting the inflammatory Group IIA sPLA2 and its associated inflammatory activities such as edema. It was found that there is a strong correlation between lipolytic activity and pro-inflammatory activity inhibition. Therefore, the study suggests that the extract processes potent anti-inflammatory agents, which could be developed as a potential therapeutic agent against inflammatory and related diseases.
机译：穿心莲（Andrographis paniculata Nees）是一种在世界热带地区发现的重要药用植物，传统上已在印度和中国的药用系统中使用。它也被用作药用食品。发现沙棘草具有抗炎活性。然而，其对炎症性IIA磷脂酶A 2 （PLA 2 ）的抑制潜力及其相关的炎症反应尚不清楚。本研究的目的是评估沙棘曲霉的乙醇提取物对罗氏沼虾（属于IIA组）炎症性PLA 2 （VRV-PL-VIIIa）的抑制/中和潜力。炎症分泌PLA 2 [sPLA 2 ]）及其在瑞士白化病小鼠中的水肿诱导活性。沙棘提取物剂量依赖性地抑制IIA组sPLA 2 的酶活性，IC 50 值为10.3±0.5μg/ ml。此外，当与酶共同注射时，提取物剂量依赖性地抑制水肿形成，表明该酶的脂解活性和促炎活性之间存在很强的相关性。总之，这项研究的结果表明，人参乙醇提取物能有效抑制IIA组sPLA 2 及其相关的炎症活性，从而证实其抗炎特性。本研究的结果值得进一步研究，以开发作为一种有效的炎性疾病治疗剂的沙棘曲霉乙醇提取物中的生物活性化合物。发明内容概述本研究通过抑制炎性IIA族sPLA2及其相关的炎性活性例如水肿而强调了沙棘曲霉的抗炎作用。已发现脂解活性和促炎活性抑制之间有很强的相关性。因此，该研究表明该提取物可处理有效的抗炎药，可将其开发为抗炎和相关疾病的潜在治疗剂。

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