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首页> 外文期刊>Pharmacognosy Research >Ameliorative Effects of Chloroform Fraction of Cocos nucifera L. Husk Fiber Against Cisplatin-induced Toxicity in Rats
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Ameliorative Effects of Chloroform Fraction of Cocos nucifera L. Husk Fiber Against Cisplatin-induced Toxicity in Rats

机译：椰壳纤维叶绿素级分对顺铂诱导的大鼠毒性的改善作用

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Background: Cisplatin (Cis) is used in the treatment of solid tumors and is known to elicit serious side effects. Objective: The present study investigated the protective effects of chloroform fraction of Cocos nucifera husk fiber (CFCN) against Cis-induced organs’ damage and chromosomal defect in rats. Quercetin (QUE), standard antioxidant, served as positive control. Materials and Methods: Thirty male Wistar rats were assigned into six groups and treated with corn oil (control), Cis alone, Cis + CFCN, CFCN alone, Cis + QUE, and QUE alone. QUE and CFCN were given at 50 and 200 mg/kg/day, respectively, by oral gavage for 7 days before the rats were exposed to a single dose of Cis (10 mg/kg, intraperitoneal) at the last 36 h of study. Results: Administration of Cis alone caused a significant ( P 0.05) affected in Cis-treated rats. Furthermore, the activities of hepatic and renal catalase, superoxide dismutase, glutathione S-transferase, glutathione peroxidase, and levels of reduced glutathione were significantly ( P 0.05) affected in Cis-treated rats. The activities of hepatic and renal catalase, superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and levels of reduced glutathione were significantly ( P <0.05) decreased in Cis-treated rats with concomitant elevation of malondialdehyde. Cis exposure increased the frequency of micronucleated polychromatic erythrocytes (mPCE) by 92%. Pretreatment with CFCN inhibited lipid peroxidation, enhanced the activities of some antioxidative enzymes and reduced the frequency of mPCE. The findings suggest that CFCN may protect against organs damage by cisplatin. Further studies are required to determine the component of the plant responsible for this activity.
机译：背景：顺铂（Cis）用于治疗实体瘤，已知会引起严重的副作用。目的：研究椰壳纤维（CFCN）的氯仿组分对顺式诱导的大鼠器官损伤和染色体缺陷的保护作用。标准抗氧化剂槲皮素（QUE）作为阳性对照。材料和方法：将三十只雄性Wistar大鼠分成六组，分别用玉米油（对照），单独的Cis，单独的Cis + CFCN，单独的CFCN，单独的Cis + QUE和QUE处理。在最后36小时的研究中，大鼠在一次单剂量Cis（10 mg / kg，腹膜内）暴露之前，分别通过口服管饲法分别以50和200 mg / kg /天的剂量给予QUE和CFCN 7天。结果：单独给予顺式肝素对经顺式肝素治疗的大鼠有显着影响（P 0.05）。此外，在顺式处理的大鼠中，肝和肾过氧化氢酶的活性，超氧化物歧化酶，谷胱甘肽S-转移酶，谷胱甘肽过氧化物酶和还原型谷胱甘肽的水平受到显着影响（P 0.05）。顺铂处理的丙二醛水平升高的大鼠肝，肾过氧化氢酶，超氧化物歧化酶，谷胱甘肽-s-转移酶，谷胱甘肽过氧化物酶的活性和谷胱甘肽还原酶的水平均显着降低（P <0.05）。顺式暴露使微核多色红细胞（mPCE）的频率增加了92％。 CFCN预处理可抑制脂质过氧化，增强某些抗氧化酶的活性，并降低mPCE的频率。研究结果表明，CFCN可以防止顺铂损害器官。需要进一步研究以确定负责该活动的植物成分。

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