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Standardization of Unani Antidiabetic Tablet - Qurse Tabasheer

机译：Unani降糖片的标准化-Qurse Tabasheer

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Background: Quality control of Unani polyherbal formulations is the need of the day for better acceptance of Unani medicine. Qurse Tabasheer (QT) is a Unani polyherbal formulation containing six ingredients, Tabasheer (Siliceous concretions) ( Bambosa arundinaceae Retz.), Gule Surkh ( Rosa damascena Mill. flower), Gulnar ( Punica granatum Linn. flower), Tukhme kahu ( Lactuca sativa Linn. seed), Tukhme khurfa ( Portulaca oleraceae Linn. seed), and Gile Armani (bole) widely used in treatment of diabetes. The present study was taken up to scientifically evaluate the various physicochemical parameters to standardize the formulation. Objective: To evaluate various physicochemical parameters including ash values, moisture content, extractive values, thin layer chromatography (TLC) and high-performance TLC (HPTLC), friability, disintegration, uniformity, and weight variation for standardization of QT. Materials and Methods: Ingredients were identified by the experts. The method mentioned in national formulary of Unani Medicine with modification was followed for preparation of the tablets. Physicochemical standards were established for ideal batch of tablets on the basis of set parameters regarding friability, hardness, and disintegration. Various parameters such as organoleptic characters, extractive values for the extract and HPTLC fingerprinting postcompression were carried out for evaluation of QT. Results: Parameters for loss of weight on drying, pH, ash values, extractive values documented. Qualitative chemical tests indicated the presence of alkaloid, glycoside, tannins, and steroids. TLC and HPTLC fingerprinting studies showing the presence of major peaks were documented. Friability, hardness, and disintegration time of ideal batch was 0.09 ± 0.0057, 4.03 ± 0.087, and 25.57 ± 0.4860 min, respectively, and it was found to be within the set limit. Weight variation was 2O3: Iron oxide Sio2: Silica CaCo3: Calcium carbonate, Tio2: Titanium Oxide NIUM: National Institute of Unani Medicine #: Mesh size LOD: Loss of weight on drying USP: United state Pharmacopeia UV: Ultra Violet λ: Lambda θ: theta CFU: Colony-forming unit.
机译：背景：对Unani多草药制剂的质量控制是当今更好地接受Unani药物的需求。 Qurse Tabasheer（QT）是一种Unani多草药配方，包含六种成分，即Tabasheer（硅质凝结物）（Bambosa arundinaceae Retz。），Gule Surkh（Rosa damascena Mill。花），Gulnar（Punica granatum Linn。花），Tukhme kahu（Lactuca sativa） Linn。种子），Tukhme khurfa（马齿race的种子）和Gile Armani（伯乐）被广泛用于治疗糖尿病。进行本研究以科学地评估各种理化参数以标准化制剂。目的：评估各种理化参数，包括灰分值，水分含量，萃取值，薄层色谱（TLC）和高性能TLC（HPTLC），易碎性，崩解性，均匀性和重量变化，以实现QT标准化。材料和方法：成分由专家鉴定。遵循在Unani Medicine的国家配方中提及的方法进行修改，以制备片剂。根据有关脆性，硬度和崩解性的设定参数，为理想批次的片剂建立了理化标准。为了评估QT，进行了各种参数，例如感官特性，提取物的提取值和HPTLC指纹图谱的后压缩。结果：记录了干燥失重，pH，灰分值，萃取值的参数。定性化学测试表明存在生物碱，糖苷，单宁和类固醇。 TLC和HPTLC指纹图谱研究表明存在主要峰。理想批料的脆性，硬度和崩解时间分别为0.09±0.0057、4.03±0.087和25.57±0.4860分钟，并且发现在设定的范围内。重量变化为2 O 3 ：氧化铁Sio 2 ：二氧化硅CaCo 3 ：碳酸钙Tio 2 < / sub>：氧化钛NIUM：美国国立Unani医学院＃：筛孔尺寸LOD：干燥失重USP：美国药典UV：紫外线λ：λθ：theta CFU：菌落形成单位。

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