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首页> 外文期刊>Pharmacology & Pharmacy >Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones
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Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

机译：一系列新的查尔酮，吡唑类和烯丙基查尔酮的合成，抗氧化和抗菌活性

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摘要

A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate. The structures of the compounds were confirmed by spectral data (infrared spectroscopy and 1H nuclear magnetic resonance). All of the compounds (4/5a-c and 11a-b) have been tested for their antimicrobial activities (agar disc-diffusion method) and antioxidant activities (1,1-biphenyl-2-picrylhydrazyl free radical scavenging method). The test compounds failed to show antibacterial properties (4a-c, 5b, and 11a-b) or exhibited such properties poorly (5a and 5c). None of the test compounds displayed antifungal properties. Of the compounds tested, compounds 5a-c and 11a-b exhibited promising antioxidant activities.
机译：通过克莱森-施密特缩合法制备了一系列新的查耳酮（4​​a-c）和烯丙基查耳酮（11a-b）。通过各自的查耳酮（4​​a-c）与水合肼的反应，合成了一系列新的吡唑基查耳酮（5a-c）。通过光谱数据（红外光谱和1H核磁共振）证实了化合物的结构。已测试所有化合物（4 / 5a-c和11a-b）的抗微生物活性（琼脂圆盘扩散法）和抗氧化剂活性（1,1-联苯-2-甲基-2-肼基自由基清除法）。测试化合物未能显示出抗菌性能（4a-c，5b和11a-b）或表现出较差的性能（5a和5c）。测试化合物均未显示出抗真菌特性。在测试的化合物中，化合物5a-c和11a-b显示出有希望的抗氧化剂活性。

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