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首页> 外文期刊>Pharmacology & Pharmacy >Interaction of Flomazenil with Anxiolytic Effects of Citrus aurantium L. Essential Oil on Male Mice
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Interaction of Flomazenil with Anxiolytic Effects of Citrus aurantium L. Essential Oil on Male Mice

机译：氟马西尼与柑桔精油对雄性小鼠抗焦虑作用的相互作用

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Due to our previous findings about the role of GABAegic neurotransmission in anxiolytic effects of Citrus aurantium L. essential oil, we are now presenting flomazenil interaction with this herb, as an antagonist of benzodiazepines at GABA receptor. The study was performed on 84 male albino mice assigned to 14 groups of six. The animals were injected intraperitoneally with the Citrus aurantium L. essential oil for 5 days. On the fifth day, either normal saline or flomazenil (0.1 mg/kg) was injected to the experimental groups. Thirty minutes after the injection, all the groups were assessed for anxiety-related behavior by elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the time spent in the open arms increased significantly (P aurantium L. essential oil regarding the increment in the number of entries to the open arms and the time spent in the open arms (P aurantium L. essential oil induces its anxiolytic effects like benzodiazepines, in the same site at GABA receptor.
机译：由于我们先前关于GABA的神经传递在柑桔香精油的抗焦虑作用中的作用的发现，我们现在提出了氟马西尼与这种草药的相互作用，作为苯二氮卓在GABA受体的拮抗剂。该研究是在84只白化病雄性小鼠中进行的，每组分为14组，每组六只。给动物腹膜内注射柑桔精油5天。在第五天，向实验组注射生理盐水或氟马西尼（0.1 mg / kg）。注射后30分钟，通过升高的迷宫测试评估所有组的焦虑相关行为。在接受浓度为2.5％和5％的柑桔香精油的组中，张开双臂所花费的时间显着增加（关于张开双臂进入次数的增加和在琴槌上所花费的时间，P金精油张开双臂（金（精油）在GABA受体的同一部位诱导其抗焦虑作用，如苯并二氮杂s。

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