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首页> 外文期刊>Journal of Behavioral and Brain Science >A Study of the Effect of Citrus aurantium L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice
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A Study of the Effect of Citrus aurantium L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice

机译：柑桔精油对雄性小鼠焦虑及其与GABA能途径的相互作用的研究

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摘要

Anxiety is among the most common disorders affecting a great number of people. Different neurotransmitter systems, such as GABAergic system, play an important role in emergence of anxiety-related behaviors. In this study, we have investigated the effect of Citrus aurantium L. essential oil on anxiety and its interaction with GABAergic pathways. Male mice were assigned into control, sham, and experimental groups. Intraperitoneal injection of Citrus aurantium L. essential oil was applied at doses of 0.5, 2.5, and 5 percent for 5 days. Diazepam (0.1 mg/kg) was injected on the fifth day, thirty minutes before applying Citrus aurantium L. essential oil. The anxiety-related behavior of mice was then assessed using elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the percent time spent in the open arms increased significantly (P Citrus aurantium L. essential oil resulted in increasing in the number of entries to the open arms and the percent time spent in the open arms (P Citrus aurantium L. essential oil can reduce anxiety-related behaviors in male mice thah may act via GABAergic system.
机译：焦虑症是影响许多人的最常见疾病之一。不同的神经递质系统，例如GABA能系统，在焦虑相关行为的发生中起重要作用。在这项研究中，我们研究了柑桔精油对焦虑的影响及其与GABA能途径的相互作用。将雄性小鼠分为对照组，假组和实验组。腹腔注射柑桔精油，剂量为0.5％，2.5％和5％，持续5天。在施用柑橘橙精油前三十分钟的第五天注射地西p（0.1 mg / kg）。然后使用升高的迷宫测试评估小鼠的焦虑相关行为。在接受浓度为2.5％和5％的柑桔香精油的组中，张开双臂花费的时间百分比显着增加（P柑桔香精油导致张开双臂的进入数量和百分比增加在张开双臂中花费的时间（P.Curtrus aurantium L.精油可以减少雄性小鼠的焦虑相关行为，这可能是通过GABA能系统起作用的。

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