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首页> 外文期刊>Pharmacogenomics and Personalized Medicine >CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome
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CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome

机译：俄罗斯中部和西伯利亚急性冠脉综合征的俄罗斯患者 CYP2C19 多态性频率

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Purpose: The aim of this study is to investigate the frequency of CYP2C19*2, *3 allelic variants, associated with poor response to clopidogrel, and CYP2C19*17 , associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia. Patients and methods: The study included 512 ACS patients who were subsequently treated with coronary arterial stenting. The subjects assigned were from the cities of Central (Novosibirsk, Kemerovo), Eastern (Irkutsk), Northern (Surgut) Siberia regions and from Moscow region. The mean age of patients enrolled was 63.9±10.9 years. Among the assigned subjects, the proportion of men accounted for 80% and women 20%. Results: According to the results obtained in the present study, from 16% up to 27.5% of patients in different regions of Russia have at least one CYP2C19 “poor metabolizer” (PM) allele variant affecting clopidogrel metabolism and, therefore, suppressing its antiplatelet activity. CYP2C19*17 allele variant was identified with the frequency of 15.4% up to 33.3%. The study revealed the presence of statistically significant differences in CYP2C19*3 allele frequency between the Russian ethnic group patients from Eastern and Central Siberia ( p =0.001; odds ratio=1.05 [95% confidence interval 1.01–1.09]). Conclusion: The study revealed statistically significant differences between the allele frequencies in Eastern and Central Siberia, which can probably be caused by a considerable number of Buryats inhabiting Eastern Siberia.
机译：目的：本研究的目的是研究急性冠脉综合征（ACS）患者中与氯吡格雷反应不良相关的CYP2C19 * 2，* 3等位基因变体和与氯吡格雷反应过度相关的CYP2C19 * 17的频率来自俄罗斯的西伯利亚和莫斯科地区。患者和方法：该研究包括512例ACS患者，这些患者随后接受了冠状动脉支架植入术。分配的主题来自中部（新西伯利亚，克麦罗沃），东部（伊尔库茨克），北部（索古特）西伯利亚地区和莫斯科地区的城市。入组患者的平均年龄为63.9±10.9岁。在分配的科目中，男性比例为80％，女性比例为20％。结果：根据本研究获得的结果，俄罗斯不同地区的患者中，有16％至27.5％的患者具有至少一种CYP2C19“弱代谢者”（PM）等位基因变体，影响氯吡格雷的代谢，因此抑制了其抗血小板活性活动。 CYP2C19 * 17等位基因变异的频率为15.4％至33.3％。该研究显示，来自西伯利亚东部和中部的俄罗斯族裔患者之间的CYP2C19 * 3等位基因频率存在统计学上的显着差异（p = 0.001;优势比= 1.05 [95％置信区间1.01-1.09]）。结论：该研究揭示了西伯利亚东部和中部等位基因频率之间的统计学显着差异，这可能是由居住在西伯利亚东部的大量布里亚特人造成的。

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