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首页> 外文期刊>Physiological Reports >Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans
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Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans

机译：长时间暴露于人类高海拔地区后，脑血管反应性和结构的变化

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AbstractAlthough high-altitude exposure can lead to neurocognitive impairment, even upon return to sea level, it remains unclear the extent to which brain volume and regional cerebral vascular reactivity (CVR) are altered following high-altitude exposure. The purpose of this study was to simultaneously determine the effect of 3 weeks at 5050 m on: (1) structural brain alterations; and (2) regional CVR after returning to sea level for 1 week. Healthy human volunteers (n = 6) underwent baseline and follow-up structural and functional magnetic resonance imaging (MRI) at rest and during a CVR protocol (end-tidal PCO2 reduced by −10, −5 and increased by +5, +10, and +15 mmHg from baseline). CVR maps (% mmHg−1) were generated using BOLD MRI and brain volumes were estimated. Following return to sea level, whole-brain volume and gray matter volume was reduced by 0.4 ± 0.3% (P  0.01) and 2.6 ± 1.0% (P  0.001), respectively; white matter was unchanged. Global gray matter CVR and white matter CVR were unchanged following return to sea level, but CVR was selectively increased (P  0.05) in the brainstem (+30 ± 12%), hippocampus (+12 ± 3%), and thalamus (+10 ± 3%). These changes were the result of improvement and/or reversal of negative CVR to positive CVR in these regions. Three weeks of high-altitude exposure is reflected in loss of gray matter volume and improvements in negative CVR.
机译：摘要尽管高海拔暴露可能导致神经认知障碍，即使返回海平面后，仍不清楚高海拔暴露后脑容量和局部脑血管反应性（CVR）改变的程度。这项研究的目的是同时确定在5050 m的3周内对以下方面的影响：（1）结构性大脑改变; （2）返回海平面1周后的区域CVR。健康的人类志愿者（n = 6）在静止和CVR方案期间（潮气末PCO 2 降低了-10，-5）进行了基线和后续结构和功能磁共振成像（MRI）并比基线增加了+ 5，+ 10和+15 mmHg）。使用BOLD MRI生成CVR图（％mmHg -1 ）并估算脑容量。返回海平面后，全脑体积和灰质体积分别减少了0.4±0.3％（P <0.01）和2.6±1.0％（P <0.001）;白质保持不变。返回海平面后，全球灰质CVR和白质CVR保持不变，但脑干（+30±12％），海马（+12±3％）和丘脑（+ 10±3％）。这些变化是这些区域中阴性CVR改善和/或逆转为阳性CVR的结果。三周的高空暴露反映为灰质体积减少和负CVR改善。

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