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New acylated aminopropane diols and their analogs, useful in the treatment of cerebral vascular disorders especially cerebral ischemia and cerebral vascular accidents
New acylated aminopropane diols and their analogs, useful in the treatment of cerebral vascular disorders especially cerebral ischemia and cerebral vascular accidents
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机译：新的酰化氨基丙烷二醇及其类似物，可用于治疗脑血管疾病，尤其是脑缺血和脑血管意外
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摘要
Acylated aminopropane diols and their analogs (I), their optical and geometric isomers, racemates, salts, and mixtures. Acylated aminopropane diols and their analogs (I), their optical and geometric isomers, racemates, salts, and mixtures [Image] G2, G3 : O, S, or N-R4, with the proviso that they are not both N-R4; R, R4 : H, optionally saturated and optionally substituted 1-5C alkyl; R1, R2, R3 : H, CO-R5, or CO-(CH 2) 2 n + 1-X-R6, at least one of these being CO-(CH 2) 2 n + 1-X-R6; R5 : optionally saturated and optionally substituted alkyl, that may contain a cyclic group and having 1-25C atoms in the main chain; X : S, Se, SO, or SO 2; n : 0 - 11; R6 : optionally saturated and optionally substituted alkyl, that may contain a cyclic group and one or more hetero groups (O, S, Se, SO or SO 2) and having 3-23C atoms in the main chain with the exclusion of those compounds of formula (I) in which G2R2 and G3R3 are both OH groups. ACTIVITY : Cerebroprotective. MECHANISM OF ACTION : Peroxisome Proliferator-Activated Receptor activators.
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机译：酰化的氨基丙烷二醇及其类似物（I），其旋光和几何异构体，外消旋物，盐和混合物。酰化氨基丙烷二醇及其类似物（I），它们的旋光和几何异构体，外消旋物，盐和混合物[图片] G2，G3：O，S或N-R4，前提是它们都不都是N-R4; R，R4：H，任选地饱和和任选取代的1-5C烷基; R1，R2，R3：H，CO-R5或CO-（CH 2）2 n + 1-X-R6，其中至少一个为CO-（CH 2）2 n + 1-X-R6; R5：可以含有环状基团且在主链上具有1〜25个碳原子的可以具有饱和取代基的烷基。 X：S，Se，SO或SO 2; n：0-11; R 6：任选饱和和任选取代的烷基，其可包含环状基团和一个或多个杂基（O，S，Se，SO或SO 2），并且在主链中具有3-23个碳原子，但不包括以下化合物式（I），其中G 2 R 2和G 3 R 3均为OH基。活动：脑保护。作用机理：过氧化物酶体增殖物激活的受体激活剂。
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