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首页> 外文期刊>Physiological Reports >Cerebral, subcortical, and cerebellar activation evoked by selective stimulation of muscle and cutaneous afferents: an fMRI study
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Cerebral, subcortical, and cerebellar activation evoked by selective stimulation of muscle and cutaneous afferents: an fMRI study

机译：选择性刺激肌肉和皮肤传入刺激诱发的大脑，皮质下和小脑激活：fMRI研究

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AbstractWe compared the brain areas that showed significant flow changes induced by selective stimulation of muscle and cutaneous afferents using fMRI BOLD imaging. Afferents arising from the right hand were studied in eight volunteers with electrical stimulation of the digital nerve of the index finger and over the motor point of the FDI muscle. Both methods evoked areas of significant activation cortically, subcortically, and in the cerebellum. Selective muscle afferent stimulation caused significant activation in motor-related areas. It also caused significantly greater activation within the contralateral precentral gyrus, insula, and within the ipsilateral cerebellum as well as greater areas of reduced blood flow when compared to the cutaneous stimuli. We demonstrated separate precentral and postcentral foci of excitation with muscle afferent stimulation. We conclude, contrary to the findings with evoked potentials, that muscle afferents evoke more widespread cortical, subcortical, and cerebellar activation than do cutaneous afferents. This emphasizes the importance, for studies of movement, of matching the kinematic aspects in order to avoid the results being confounded by alterations in muscle afferent activation. The findings are consistent with clinical observations of the movement consequences of sensory loss and may also be the basis for the contribution of disturbed sensorimotor processing to disorders of movement.
机译：摘要我们比较了使用fMRI BOLD成像技术选择性刺激肌肉和皮肤传入神经所引起的明显流量变化的大脑区域。在八名志愿者中对右手产生的传入神经进行了研究，他们对食指的手指神经和FDI肌肉的运动点进行了电刺激。两种方法都在皮质，皮质下和小脑中引起明显的激活区域。选择性肌肉传入刺激在运动相关区域引起明显的激活。与皮肤刺激相比，它还引起对侧中央前回，岛状和同侧小脑内部明显更大的激活，以及更大范围的血流减少。我们展示了肌肉传入刺激刺激的单独的中央和中央后焦点。与具有诱发电位的发现相反，我们得出的结论是，肌肉传入神经引起的皮层，皮层下和小脑激活比皮肤传入神经更广泛。对于运动的研究，这强调了匹配运动学方面的重要性，以避免结果由于肌肉传入激活的改变而混淆。该发现与感觉丧失的运动后果的临床观察结果一致，并且也可能是感觉运动过程受干扰导致运动障碍的基础。

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