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首页> 外文期刊>Pharmacognosy magazine >Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology
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Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

机译：用响应面法优化中药配方药黄玉堂汤中7种生物活性化合物的提取工艺

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Background:Yukmijihwang-tang (YJT) contains multiple bioactive compounds. Heat-reflux extraction was employed and optimized for the extraction of the bioactive compounds in YJT.Objective:The determination of optimal conditions with maximum yields of bioactive compounds, gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, paeoniflorin, benzoic acid and paeonol, in YJT.Materials and Methods:The extraction ratio (ratio of water to herbal formula), extraction time and extraction number were set as individual values and the yields of the seven compounds were the response values that were optimized with a Box–Behnken design.Results:The optimal conditions obtained from response surface methodology (RSM) were 1:11.99 for the extraction ratio, 94.53 min for the extraction time and 2.21 for the extraction number. Under the optimal conditions, the response value of the experiment closely agreed with the predicted response value.Conclusions:The result suggests that RSM is successfully applied for optimizing the extraction of the marker compounds in YJT.
机译：背景：Yukmijihwang-tang（YJT）包含多种生物活性化合物。目的：以最大的生物活性化合物，没食子酸，5-羟甲基糠醛，桑ron苷，loganin，pa药苷，苯甲酸和丹皮酚的收率确定最佳条件，确定最佳条件。材料和方法：将萃取比（水与草药配方的比），萃取时间和萃取次数设置为单个值，并使用Box–Behnken设计优化了这7种化合物的收率。结果：从响应面法（RSM）获得的最佳提取条件为：提取比例为1：11.99，提取时间为94.53min，提取数为2.21。在最佳条件下，实验的响应值与预测的响应值非常吻合。结论：结果表明RSM已成功应用于YJT中标记化合物的提取。

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