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首页> 外文期刊>Pharmacognosy magazine >Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice
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Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice

机译：黄芪总皂甙IV与三七有效成分联合对小鼠脑缺血再灌注后氧化应激损伤及核因子-类胡萝卜素2相关因子2 /血红素加氧酶-1信号通路的影响

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Background:Astragalus and Panax notoginseng are traditional Chinese Medicines used for the treatments of ischemic cerebrovascular disease, being often combined together in China and achieving a good effect.Objective:The objective of this study is to investigate the effects of astragaloside-IV (AST-IV) (the effective component of Astragalus) combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 (the effective components of P. notoginseng) on oxidative stress injury after cerebral ischemia-reperfusion in mice, and to explore the mechanisms through nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway.Materials and Methods:C57BL/6 mice were randomly grouped after treated for 3 days, the model of cerebral ischemia-reperfusion injury was established, and the brain tissues were detected.Results:AST-IV combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 could increase significantly the survival rate of nerve cell; decrease the contents of malondialdehyde, nitric oxide, increase the activity of superoxide dismutase and the level of glutathione; Nrf2 was down-regulated in the cytoplasm while up-regulated in nucleus, nuclear translocation rate raised as well as HO-1 messenger ribonucleic acid and protein expressions increased. The effects of four active components combination were better than those of the active components alone.Conclusion:Active components of Astragalus and P. notoginseng had the effects against cerebral ischemia-reperfusion injury, which were related to the antioxidative stress after cerebral ischemia-reperfusion. AST-IV combined with ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 could strengthen the antagonism effects on ischemia-reperfusion and oxidative stress injury, the mechanism underlying might be associated with jointly activating Nrf2/HO-1 signaling pathway after cerebral ischemia-reperfusion.
机译：背景：黄芪和三七是用于治疗缺血性脑血管疾病的中药，在中国经常联合使用并取得良好的疗效。目的：本研究的目的是研究黄芪甲苷-IV（AST- IV）（黄芪的有效成分）与人参皂甙Rg1，人参皂甙Rb1，三七皂甙R1（三七的有效成分）联合对小鼠脑缺血再灌注后的氧化应激损伤，并通过核因子-类胡萝卜素探索其机制2相关因子-2 /血红素加氧酶-1（Nrf2 / HO-1）信号通路。材料与方法：C57BL / 6小鼠经3天随机分组，建立脑缺血再灌注损伤模型，并建立脑缺血再灌注损伤模型。结果：AST-IV联合人参皂苷Rg1，人参皂苷Rb1，三七皂苷R1能明显提高神经细胞的存活率。降低丙二醛，一氧化氮的含量，增加超氧化物歧化酶的活性和谷胱甘肽的水平; Nrf2在细胞质中下调，而在细胞核中上调，核转运速率提高，HO-1信使核糖核酸和蛋白质表达增加。结论：黄芪和三七的有效成分具有抗脑缺血再灌注损伤的作用，这与脑缺血再灌注后的抗氧化应激有关。 AST-IV与人参皂甙Rg1，人参皂甙Rb1，三七皂甙R1联合可增强对缺血再灌注和氧化应激损伤的拮抗作用，其机制可能与共同激活脑缺血再灌注后的Nrf2 / HO-1信号通路有关。

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