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首页> 外文期刊>PLoS Biology >Bulge, Bubble, and Y: How an RNA Exonuclease Repairs DNA, in Detail
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Bulge, Bubble, and Y: How an RNA Exonuclease Repairs DNA, in Detail

机译:凸起,气泡和Y:RNA外切核酸酶如何修复DNA

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摘要

For a cell, it's not so much death or taxes, but damage to its DNA, that is inevitable. Chemicals, radiation, and ultraviolet light all take their toll, disrupting the double helix and leaving dangerous chaos in their wake. The genome in virtually every cell in every organism suffers such damage multiple times over its lifespan. Left unrepaired, such disruptions would quickly leave the cell either unable to survive, or perhaps unable to check its own growth. Many tumors get their start when a damaged gene is unsuccessfully repaired.
机译:对于一个细胞而言,死亡和税负不是很多,而是对其DNA的损害是不可避免的。化学物质,辐射和紫外线都会造成人员伤亡,破坏双螺旋结构,并在危险中留下危险的混乱。实际上,每个生物体中每个细胞中的基因组在其生命周期中都会遭受多次此类破坏。如果不加以修复,这种破坏将迅速使细胞无法生存,或者可能无法检查其自身的生长。受损基因修复失败后,许多肿瘤就会开始。

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