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首页> 外文期刊>PLoS Genetics >Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation
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Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

机译：异色基因组稳定性需要组蛋白H3 K9甲基化的调节剂

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Heterochromatin contains many repetitive DNA elements and few protein-encoding genes, yet it is essential for chromosome organization and inheritance. Here, we show that Drosophila that lack the Su(var)3-9 H3K9 methyltransferase display significantly elevated frequencies of spontaneous DNA damage in heterochromatin, in both somatic and germ-line cells. Accumulated DNA damage in these mutants correlates with chromosomal defects, such as translocations and loss of heterozygosity. DNA repair and mitotic checkpoints are also activated in mutant animals and are required for their viability. Similar effects of lower magnitude were observed in animals that lack the RNA interference pathway component Dcr2. These results suggest that the H3K9 methylation and RNAi pathways ensure heterochromatin stability.
机译：异染色质包含许多重复的DNA元素和很少的蛋白质编码基因，但它对于染色体的组织和遗传至关重要。在这里，我们表明，缺乏Su（var）3-9 H3K9甲基转移酶的果蝇在体细胞和种系细胞中均显示异染色质中自发DNA损伤的频率显着升高。这些突变体中累积的DNA损伤与染色体缺陷相关，例如易位和杂合性丧失。 DNA修复和有丝分裂检查点在突变动物中也被激活，它们的生存能力是必需的。在缺少RNA干扰途径成分Dcr2的动物中观察到了较低幅度的类似影响。这些结果表明，H3K9甲基化和RNAi途径可确保异染色质的稳定性。

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