...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLoS Genetics >TGF-? Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging
【24h】

TGF-? Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging

机译：TGF-？ Sma / Mab信号突变使生殖衰老与体细胞衰老脱钩

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Female reproductive cessation is one of the earliest age-related declines humans experience, occurring in mid-adulthood. Similarly, Caenorhabditis elegans' reproductive span is short relative to its total life span, with reproduction ceasing about a third into its 15–20 day adulthood. All of the known mutations and treatments that extend C. elegans' reproductive period also regulate longevity, suggesting that reproductive span is normally linked to life span. C. elegans has two canonical TGF-? signaling pathways. We recently found that the TGF-? Dauer pathway regulates longevity through the Insulin/IGF-1 Signaling (IIS) pathway; here we show that this pathway has a moderate effect on reproductive span. By contrast, TGF-? Sma/Mab signaling mutants exhibit a substantially extended reproductive period, more than doubling reproductive span in some cases. Sma/Mab mutations extend reproductive span disproportionately to life span and act independently of known regulators of somatic aging, such as Insulin/IGF-1 Signaling and Dietary Restriction. This is the first discovery of a pathway that regulates reproductive span independently of longevity and the first identification of the TGF-? Sma/Mab pathway as a regulator of reproductive aging. Our results suggest that longevity and reproductive span regulation can be uncoupled, although they appear to normally be linked through regulatory pathways.
机译：女性生殖停止是人类经历的最早与年龄有关的衰落之一，发生在成年中期。同样，秀丽隐杆线虫的生殖距离相对于其总寿命短，成年后15至20天的生殖时间减少了约三分之一。延长秀丽隐杆线虫生殖期的所有已知突变和治疗方法也可调节寿命，这表明生殖跨度通常与寿命相关。秀丽隐杆线虫有两个典型的TGF-β？信号通路。我们最近发现TGF-？ Dauer途径通过胰岛素/ IGF-1信号传导（IIS）途径调节寿命。在这里，我们表明该途径对生殖跨度有中等影响。相比之下，TGF-β？ Sma / Mab信号突变体的繁殖期大大延长，在某些情况下繁殖跨度增加了一倍以上。 Sma / Mab突变使生殖跨度不成比例地延长至寿命，并且独立于体细胞衰老的已知调节剂而起作用，例如胰岛素/ IGF-1信号传导和饮食限制。这是首次独立于寿命调节生殖跨度的途径的发现，也是对TGF-β的首次鉴定。 Sma / Mab途径可作为生殖衰老的调节剂。我们的结果表明，尽管寿命和生殖跨度调节通常似乎通过调节途径联系在一起，但它们可以分开。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号