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Genome Network and FANTOM3: Assessing the Complexity of the Transcriptome

机译:基因组网络和FANTOM3:评估转录组的复杂性

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The findings of the FANTOM3/Genome Network project have redefined the landscape of the mammalian transcriptome by introducing an extensive collection of novel cDNAs and millions of sequenced tags corresponding to 5′- and 3′-ends of mRNAs. This issue of PLoS Genetics includes a special collection of articles that explore the transcriptome complexity being revealed by work on the FANTOM3 dataset. Besides revealing staggering complexity, analysis of this collection is providing an increasing number of novel mRNA classes, expressed pseudogenes, and bona fide noncoding variants of protein-coding genes. In addition, new types of regulatory logic have emerged, including sense–antisense mechanisms of RNA regulation. This high-resolution cDNA collection and its analysis represent an important world resource for discovery, and demonstrate the value of large-scale transcriptome approaches towards understanding genome function.
机译:FANTOM3 /基因组网络项目的发现通过引入大量的新颖cDNA和与mRNA的5'-和3'-端相对应的数百万个测序标签,重新定义了哺乳动物转录组的格局。本期《公共科学图书馆·遗传学》(PLoS Genetics)包括一组特殊的文章,这些文章探讨了通过FANTOM3数据集揭示的转录组复杂性。除了揭示惊人的复杂性外,对该集合的分析还提供了越来越多的新颖mRNA类型,表达的假基因和蛋白质编码基因的真正非编码变体。此外,出现了新型的调节逻辑,包括RNA调节的有义反义机制。这种高分辨率的cDNA收集及其分析代表了重要的世界发现资源,并证明了大规模转录组方法对于理解基因组功能的价值。

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