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首页> 外文期刊>PLOS Neglected Tropical Diseases >The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls
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The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls

机译：棘形棘阿米巴（Acanthamoeba castellanii）最丰富的囊壁蛋白是凝集素，可与纤维素结合并定位于发育中和成熟囊壁的不同结构

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Author summary A half century ago, investigators identified cellulose in the Acanthamoeba cyst wall, which has two layers and conical ostioles that connect them. Here we showed cyst walls contain three large sets of cellulose-binding lectins, which localize to the ectocyst layer (a Jonah lectin) or to the endocyst layer and ostioles (Luke and Leo lectins). We used the lectins to establish a sequence for cyst wall assembly when trophozoites are starved and encyst. In the first stage, a Jonah lectin and glycopolymers were present in dozens of distinct vesicles. In the second stage, a primordial wall contained small, flat ostioles outlined by a Luke lectin. In the third stage, a Jonah lectin remained in the ectocyst layer, while Luke and Leo lectins moved to the endocyst layer and ostioles. A description of the major events during cyst wall development is a starting point for mechanistic studies of its assembly.
机译：作者摘要半个世纪前，研究人员在棘阿米巴囊壁中发现了纤维素，该壁具有两层和连接它们的圆锥形心室。在这里，我们显示出囊壁中包含三套大的纤维素结合凝集素，它们定位在胞囊层（乔纳菌凝集素）或内囊层和牛骨（Luke和Leo凝集素）上。我们使用凝集素来建立滋养体饥饿和包囊时囊壁组装的顺序。在第一阶段，约纳凝集素和糖聚合物存在于数十个不同的囊泡中。在第二阶段，原始壁包含由Luke凝集素勾勒出的小而平坦的心房。在第三阶段，约拿凝集素保留在胞囊层中，而卢克和利奥凝集素则移至内囊层和牛耳。对囊肿壁发育过程中主要事件的描述是其组装机理研究的起点。

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