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首页> 外文期刊>PLoS One >Thrombosis after liver transplantation for hepatocellular carcinoma
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Thrombosis after liver transplantation for hepatocellular carcinoma

机译：肝癌肝移植术后血栓形成

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The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. We investigated a cohort of patients who underwent LT for HCC with the aim to estimate the incidence rate (IR) of thrombosis, its influence on mortality and re-transplantation rates and, in the frame of a nested case-control study, the role of thrombophilia in donors and recipients for the development of thrombosis. Four-hundred and thirty patients underwent LT and were followed for a median of 7.2 years. Twenty-six recipients (6%) developed thrombosis (IR 1.06 [95%CI: 0.71–1.53] per 100 pts-yr). Mortality rate after LT was 3.95 (95%CI: 3.22–4.79) per 100 pts-yr and was not influenced by thrombosis. Re-transplantation was planned for 33 patients and was more common in patients with thrombosis than in those without (HR 2.50 [95%CI: 0.87–7.17]). The risk of thrombosis was 4 times higher in recipients with thrombophilia than in those without (OR 4.23 [95%CI: 0.99–18.04]) and 6 times higher when the analysis was restricted to venous thrombosis (OR 6.26 [95%CI: 1.19–32.85]). The presence of inherited thrombophilia in the donors did not increase the risk of thrombosis of the recipient. In conclusion, thrombosis is a complication of 6% of patients transplanted for HCC and increases the risk of re-transplantation but not of mortality. The risk of thrombosis, particularly venous, is increased in the presence of thrombophilia abnormalities in the recipients.
机译：尚不清楚血栓形成对肝移植（LT）后肝细胞癌（HCC）患者预后的影响以及最常见的遗传性血友病异常因子V Leiden和凝血酶原G20210A在血栓形成中的作用。我们调查了接受LT肝癌治疗的一组患者，目的是评估血栓形成的发生率（IR），血栓形成对死亡率和再移植率的影响以及在巢式病例对照研究的框架内的作用。在供血者和接受者中形成血栓形成性血栓形成。 430例患者接受了LT，平均随访时间为7.2年。 26位接受者（6％）发生了血栓形成（每100 pts-yr IR 1.06 [95％CI：0.71-1.53​​]）。 LT后的死亡率为每100 pts-yr 3.95（95％CI：3.22–4.79），并且不受血栓形成的影响。计划再移植33例，有血栓形成的患者比没有血栓形成的患者更常见（HR 2.50 [95％CI：0.87–7.17]）。有血栓形成倾向的接受者的血栓形成风险比没有血栓形成的患儿高4倍（OR 4.23 [95％CI：0.99-18.04]），而仅限于静脉血栓形成的分析者有6倍的血栓形成风险（OR 6.26 [95％CI：1.19] –32.85]）。供体中遗传性血栓形成的存在并未增加接受者血栓形成的风险。总之，血栓形成是接受肝癌移植的患者的6％，增加了再移植的风险，但没有增加死亡率。在接受血栓形成异常的患者中，血栓形成（尤其是静脉）的风险增加。

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