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首页> 外文期刊>PLOS Neglected Tropical Diseases >Population genomics of Culiseta melanura, the principal vector of Eastern equine encephalitis virus in the United States
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Population genomics of Culiseta melanura, the principal vector of Eastern equine encephalitis virus in the United States

机译：美国东部马脑炎病毒的主要载体Culiseta melanura的种群基因组学

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Author summary Eastern equine encephalitis (EEE) is a highly pathogenic mosquito-borne virus responsible for outbreaks of severe disease in humans and equines, causing high mortality and neurological impairment in most survivors. In the past, human disease outbreaks in the northeastern United States occurred intermittently; however, recently, this region has experienced a recurring seasonal intensification of EEE virus activity with expansion into more northerly locales. Eastern equine encephalitis virus is maintained in a transmission cycle involving the ornithophilic mosquito, Culiseta melanura, and wild passerine birds in freshwater swamp foci. Recent studies on the blood feeding behavior of Cs. melanura suggest this mosquito species could also be involved in transmission of EEE virus to humans and equines. Since variation in host feeding of this mosquito vector may be a function of environmental factors and/or genetic differences among regional populations, we examined the population genetics of Cs. melanura in order to: 1) characterize the genetic diversity of Cs. melanura at EEE virus foci across eastern North America, 2) investigate the occurrence of genetic structure among populations of Cs. melanura, and 3) examine patterns of gene flow among these populations. We generated a draft genome of this species as a reference for population studies, identified evidence of significant genetic differentiation and fine-scale genetic structure among populations, and found evidence of gene flow among northeastern populations. This study provides the molecular basis for future investigations on the causes and consequences of the genomic variation in Cs. melanura on the risk of human and equine infection with EEE virus.
机译：作者摘要东部马脑炎（EEE）是一种高致病性蚊媒病毒，引起人类和马的严重疾病暴发，在大多数幸存者中引起高死亡率和神经系统损害。过去，美国东北部的人类疾病爆发是间歇性发生的;但是，最近该地区的EEE病毒活动季节性反复加剧，并向更北部地区扩展。东部马脑炎病毒以传播周期维持，包括嗜食性蚊子，黑斑病蚊和淡水沼泽地中的野生雀形目鸟类。 Cs的血液喂养行为的最新研究。 melanura认为这种蚊子也可能与EEE病毒向人和马的传播有关。由于这种蚊媒的寄主摄食变化可能是环境因素和/或区域人群之间遗传差异的函数，因此我们研究了Cs的种群遗传学。 melanura为了：1）表征Cs的遗传多样性。北美东部EEE病毒病灶的黑斑病（2）调查了Cs人群中遗传结构的发生。 melanura和3）研究了这些种群之间的基因流动模式。我们生成了该物种的基因组草案，以供种群研究参考，确定了种群之间显着的遗传分化和精细规模的遗传结构的证据，并发现了东北种群之间的基因流的证据。这项研究为进一步研究Cs基因组变异的原因和后果提供了分子基础。黑色素对人和马感染EEE病毒的风险。

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