HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study

Wei-Li Xu; Nancy L. Pedersen; Lina Keller; Grégoria Kalpouzos; Hui-Xin Wang; Caroline Graff; Bengt Winblad; Lars B?ckman; Laura Fratiglioni

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HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study

机译：HHEX_23 AA基因型加重糖尿病对痴呆症和阿尔茨海默氏病的影响：一项基于人群的纵向研究

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Background Research has suggested that variations within the IDE/HHEX gene region may underlie the association of type 2 diabetes with Alzheimer disease (AD). We sought to explore whether IDE genes play a role in the association of diabetes with dementia, AD, and structural brain changes using data from two community-based cohorts of older adults and a subsample with structural MRI.

机译：背景研究表明，IDE / HHEX基因区域内的变异可能是2型糖尿病与阿尔茨海默病（AD）关联的基础。我们试图利用来自两个基于社区的老年人群的数据和带有结构MRI的子样本，探索IDE基因是否在糖尿病与痴呆，AD和结构性脑变化的关联中发挥作用。

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《PLoS Medicine》 |2015年第7期|共20页
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Wei-Li Xu; Nancy L. Pedersen; Lina Keller; Grégoria Kalpouzos; Hui-Xin Wang; Caroline Graff; Bengt Winblad; Lars B?ckman; Laura Fratiglioni;
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1. Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study. [J] . Qiu C, Xu W, Winblad B, Journal of Alzheimer's disease: JAD . 2010,第1期

机译：老年痴呆症和阿尔茨海默氏病的血管风险概况：一项基于人群的纵向研究。
2. Rethinking the dementia diagnoses in a population-based study: what is Alzheimer's disease and what is vascular dementia?. A study from the kungsholmen project. [J] . Aguero-Torres H, Kivipelto M, von-Strauss E Dementia and geriatric cognitive disorders . 2006,第3期

机译：重新思考痴呆症诊断在基于人群的研究中：阿尔茨海默病的疾病是什么，血管痴呆症是什么？ Kungsholmen项目的研究。
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机译：在以人群为基础的阿尔茨海默氏病人群中，颅脑外伤与认知和功能障碍的进展速度之间的关系：吉尔伯特等人的Cache县痴呆病进展研究颅脑外伤对痴呆病进展的后期影响
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机译：阿尔茨海默氏病，帕金森氏病痴呆症，路易体痴呆症和健康控制之间的葡萄糖代谢性大脑网络的模块差异*
5. An examination of occupational and occupationally defined electromagnetic exposures and dementia, vascular dementia, cognitive impairment, and Alzheimer's disease in the Honolulu Asia aging study cohort. [D] . Oyama, Jody Camille Puanani. 1999

机译：在檀香山亚洲老龄化研究队列中对职业性和职业性电磁暴露和痴呆症，血管性痴呆，认知障碍和阿尔茨海默氏病进行检查。
6. HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study [O] . Wei-Li Xu, Nancy L. Pedersen, Lina Keller, 2015

机译：HHEX_23 AA基因型加重糖尿病对痴呆症和阿尔茨海默氏病的影响：一项基于人群的纵向研究
7. HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study. [O] . Wei-Li Xu, Nancy L Pedersen, Lina Keller, 2015

机译：HHEX_23 aa基因型加剧了糖尿病对痴呆和阿尔茨海默病的影响：基于人群的纵向研究。
8. Recognition and Initial Assessment of Alzheimer's Disease and Related Dementias.Clinical Practice Guideline Number 19; Early Identification of Alzheimer's Disease and Related Dementias. Quick Reference Guide for Clinicians Number 19; Early Alzheimer's Dis [R] . Costa, P. T., Williams, T. F., Albert, M. S., 1996

机译：阿尔茨海默病和相关痴呆的认可和初步评估。临床实践指南第19号;阿尔茨海默病及相关痴呆的早期鉴定。临床医生快速参考指南第19号;早期阿尔茨海默氏症

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study

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